Hepatic toxicity and uroporphyrinogen decarboxylase activity following a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin to mice.
Hepatic toxicity and uroporphyrinogen decarboxylase activity following a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin to mice.
复制标题
小鼠单剂量 2,3,7,8-四氯二苯并-p-二恶英后的肝毒性和尿卟啉原脱羧酶活性。
DOI：
10.1016/0006-2952(81)90421-4
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发表时间：
1981
影响因子：
5.8
通讯作者：
J. B. Greig
中科院分区：
文献类型：
--
作者：
A. Smith;J. Francis;S. J. Kay;J. B. Greig
单次、低致死性、口服剂量的2，3，7，8-四氯二苯并-对-二恶英（TCDD）（75 μg/kg）可诱导C57 BL/10小鼠的肝卟啉病。肝卟啉水平在给药后4-6周达到最大值，并且在给药后12周仍然升高。肝尿卟啉原脱羧酶的活性在给药后一周内受到抑制，这似乎先于卟啉症的发作。DBA/2品系小鼠在1200 μg/kg剂量下卟啉水平或75 μg/kg剂量下脱羧酶活性未显示相同幅度的变化。在两种品系中，在75 μg/kg剂量后3周，肝脏铁含量增加。雌性C57 BL/10小鼠比雄性小鼠对TCDD的致死作用更具抵抗力。
A single, low-lethality, oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (75 μg/kg) induces an hepatic porphyria in C57BL/10 mice of either sex. The hepatic porphyrin levels are maximal 4–6 weeks after dosing and are still elevated 12 weeks after the dose. The activity of hepatic uroporphyrinogen decarboxylase is depressed within one week of the dose and this appears to precede the onset of porphyria. Mice of the DBA/2 strain show no changes of the same magnitude at doses of 1200 μg/kg, for porphyrin levels, or 75 μg/kg, for decarboxylase activity. In both strains there is an increase in hepatic iron content 3 weeks after the 75 μg/kg dose. Female C57BL/10 mice are more resistant than males to the lethal effects of TCDD.