Multiple roles of timing in somite formation.
Multiple roles of timing in somite formation.
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DOI：
10.1016/j.semcdb.2015.06.002
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发表时间：
2015-06
影响因子：
7.3
通讯作者：
Piatkowska AM
中科院分区：
文献类型：
--
作者：
Stern CD;Piatkowska AM
在发育过程中，脊椎动物胚胎在中线两侧产生一系列重复的元素，即体节。它们生成脊柱、骨骼肌肉和真皮。它们从尾部附近的间充质组织依次形成，一次形成一对。体节发育是一个复杂的过程。胚胎必须控制体节形成的数量、大小和时间，它们沿着三个轴细分为功能区，区域特性使体节以区域特有的方式发育，以及与邻近组织的相互作用使它们与附近的结构协调。在这里，我们讨论了许多与时间相关的机制，它们有助于建立空间模式。
During development, vertebrate embryos produce serially repeated elements, the somites, on each side of the midline. These generate the vertebral column, skeletal musculature and dermis. They form sequentially, one pair at a time, from mesenchymal tissue near the tail. Somite development is a complex process. The embryo must control the number, size, and timing of somite formation, their subdivision into functional regions along three axes, regional identity such that somites develop in a region-specific way, and interactions with neighbouring tissues that coordinate them with nearby structures. Here we discuss many timing-related mechanisms that contribute to set up the spatial pattern.