Impairment of Online Control of Hand and Eye Movements in a Monkey Model of Optic Ataxia
Impairment of Online Control of Hand and Eye Movements in a Monkey Model of Optic Ataxia
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DOI：
10.1093/cercor/bhs250
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发表时间：
2013-11-01
期刊：
影响因子：
3.7
通讯作者：
Caminiti, Roberto
中科院分区：
文献类型：
--
作者：
Battaglia-Mayer, Alexandra;Ferrari-Toniolo, Simone;Caminiti, Roberto
通过结合单细胞记录和猴子上顶叶区域 5（PE/PEc；SPL）的可逆失活，研究了在线控制手轨迹的顶叶机制，当目标位置意外改变时，猴子会伸手和扫视视觉目标。神经活动由手部位置、速度和运动方向以及扫频前和/或扫频后信号调节。双侧蝇蕈醇注射后，观察到针对第一和第二目标的手反应和运动时间增加。这导致轨迹校正所需的时间增加，因此导致朝向第一目标位置的手路径延长。此外，手部轨迹的形状与对照组不同。还观察到眼睛对第一和第二目标的反应时间延长，这可以部分解释手部运动的规划和校正的缺陷。这些结果表明顶上小叶是在线控制手和眼运动的关键节点，并强调了眼睛损伤在迄今为止被视为视神经共济失调标志的伸手障碍出现中的作用。
The parietal mechanisms for online control of hand trajectory were studied by combining single-cell recording and reversible inactivation of superior parietal area 5 (PE/PEc; SPL) of monkeys while these made reaches and saccades to visual targets, when the target position changed unexpectedly. Neural activity was modulated by hand position, speed, and movement direction, and by pre- and/or postsaccadic signals. After bilateral muscimol injection, an increase in the hand reaction- and movement-time toward both the first and second targets was observed. This caused an increase in the time necessary for the trajectory correction, and therefore an elongation of the hand-path toward the first target location. Furthermore, hand trajectories were different in shape than control ones. An elongation of the eye reaction time to both first and second targets was also observed, which could partially explain the deficit of planning and correction of hand movement. These results identify the superior parietal lobule as a crucial node in the online control of hand and eye movement and highlight the role of the eye impairment in the emergence of the reaching disorder so far regarded as the hallmark of optic ataxia.