Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People's Republic of China.
Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People's Republic of China.
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脉冲染料激光治疗鲜红斑痣：中华人民共和国山东省 848 例病例的回顾性研究。
DOI：
10.2147/dddt.s71710
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Shi W;Wang J;Lin Y;Geng J;Wang H;Gong Y;Liu H;Zhang F
目前，595 nm脉冲染料激光（PDL）治疗是治疗鲜红斑痣（PWSs）的有效方法之一。然而，PDL的疗效在不同人群中存在差异。本研究旨在研究595 nm PDL治疗III至IV型皮肤中国患者PWS的疗效和相关因素。本研究共纳入848例接受PDL治疗的病例并进行分析。一位独立的皮肤科医生根据治疗前后的照片对这些病变进行了评估。848例PWS患者的有效率（RR）为69.9%，其中治愈率为6.3%。年龄≤1岁的患者的RR最高（93.9%），而50岁以后接受治疗的患者的RR最差（RR =25%）。我们分析了病变的解剖分布，发现颞区的病变清除率最高（RR =75.3%），而四肢的清除率最低（RR =44.5%）。与病灶大于80 cm 2的患者相比，病灶较小（0-20 cm 2）的患者临床疗效更好（RR = 73.8%vs 53.2%）。增生性病变患者的反应较红斑性病变患者差（RR = 36.4%vs71.7%）。同样，增加治疗次数可以实现更高的清除率（P=0.005）。PDL在中国PWS患者中具有相对较高的RR，但清除率较低，尽管干预越早，疗效越好。PDL的反应不仅与解剖区域有关，而且与病变大小、病变类型（即存在增生性病变）和治疗次数有关，所有这些对于评价治疗效果和在治疗前获得患者知情同意至关重要。
Currently, 595 nm pulsed dye laser (PDL) therapy is offered as one of the effective treatments of port wine stains (PWSs). However, the efficacy of PDL differs in different populations. The purpose of the study was to investigate the efficacy, and related factors, of 595 nm PDL in the treatment of PWSs in Chinese patients with skin type III to IV. A total of 848 cases that were treated with PDL were enrolled and analyzed in this study. An independent dermatologist evaluated these lesions according to the before and after photographs. The response rate (RR) of all the 848 PWS patients was 69.9%, within which the cure rate was 6.3%. The patients aged ≤1 year had the highest RR (93.9%), whereas those treated after age 50 reacted the worst (RR =25%). We analyzed the anatomical distribution of the lesion and found that the temporal region had the highest lesion clearance (RR =75.3%), while the extremities had the lowest clearance (RR =44.5%). Compared with the patients whose lesion size was larger than 80 cm2, the patients with small lesion size, of 0–20 cm2, had better clinical effect (RR =73.8% vs 53.2%). The reactions of the patients with hyperplastic lesion were worse than those with red patches (RR =36.4% vs 71.7%). As well, increasing treatment numbers could achieve higher clearance rates (P=0.005). The PDL had a relatively high RR but a low clearance rate in Chinese patients with PWS, although the earlier the intervention, the better was the efficacy. The response of PDL was, not only related to the anatomical area, but also, to the lesion size, type of lesion (ie, the presence of existing hyperplastic lesions), and the number of treatment, all of which are essential for the evaluation of therapeutic effect and acquisition of patients consent before treatment.