THE INTERACTION OF EXTRAVASCULAR PRESSURE FIELDS AND FLUID EXCHANGE IN CAPILLARY NETWORKS
THE INTERACTION OF EXTRAVASCULAR PRESSURE FIELDS AND FLUID EXCHANGE IN CAPILLARY NETWORKS
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DOI：
10.1016/0025-5564(86)90134-3
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发表时间：
1986-12-01
影响因子：
4.3
通讯作者：
GROSS, JF
中科院分区：
文献类型：
--
作者：
FLEISCHMAN, GJ;SECOMB, TW;GROSS, JF
先前开发的模型 [4] 被扩展为包括现实三维结构的毛细管网络，并用于检查局部组织压力场与液体交换的相互作用。使用该模型进行的流体通量计算表明，相互作用会随着毛细管段数量的增加而增加，该相互作用将预测的流体交换量降低到低于经典斯塔林假设的预测值。来自一根毛细管的流体过滤受到其他毛细管的局部压力场的影响，从而导致毛细管-毛细管相互作用。这种相互作用随着内皮与组织水力传导率的比率值的增加而增加。对于较大的比率值，该模型预测的流体通量比 Starling 假设计算的流体通量低近 90%。然而，研究表明，即使在该比率的最小生理合理值下，相互作用仍然对减少大型网络中预测的流体交换具有显着影响。
A previously developed model [4] is extended to include capillary networks of realistic three-dimensional architecture, and used to examine the interaction of the local tissue pressure field with fluid exchange. Fluid-flux calculations using this model show that interaction, which reduces the predicted amount of fluid exchanged below that predicted by the classical Starling''s hypothesis, increases with increasing numbers of capillary segments. Fluid filtration from one capillary is affected by the local pressure fields of other capillaries, resulting in a capillary-capillary interaction. This interaction increases with increasing values of the ratio of endothelial to tissue hydraulic conductivities. For large values of the ratio, the model predicts a fluid flux almost 90% less than that calculated by Starling''s hypothesis. It is shown, however, that at even the smallest physiologically reasonable value of this ratio, interaction still has a significant effect in reducing the predicted fluid exchange in large networks.