Travel-Associated Health Risks for Patients With Inflammatory Bowel Disease
Travel-Associated Health Risks for Patients With Inflammatory Bowel Disease
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DOI：
10.1016/j.cgh.2011.10.025
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发表时间：
2012-02-01
影响因子：
12.6
通讯作者：
Avidan, Benjamin
中科院分区：
文献类型：
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作者：
Ben-Horin, Shomron;Bujanover, Yoram;Avidan, Benjamin
背景与目的：关于炎症性肠病 (IBD) 患者旅行风险的数据很少。我们评估了 IBD 患者旅行时的患病率。方法：我们对 1099 次总旅行中的 222 名 IBD 患者和 224 名健康个体（对照）进行了一项回顾性病例对照研究。通过结构化问卷、个人访谈和图表审查来检索数据。结果：参与者在旅行期间发病 142 次； 92%是肠道疾病。 IBD 患者的 79/523 (15.1%) 次旅行中发生了疾病发作，而对照组的这一比例为 63/576 (10.9%)（优势比 [OR]，1.44；95% 置信区间 [CI]，1.01-2.0；P=.04）。然而，这种差异主要归因于在工业化国家旅行的 IBD 患者的发病率增加。相比之下，前往发展中国家的旅行者中 IBD 患者和对照组的患病率相似（分别为 34/200、17% 和 52/243、21%；P=.24）。此外，从数量上看，前往热带地区旅行的对照者患上疾病的人数多于患有 IBD 的旅行者（分别为 43/135 和 23/97；P=.18）。在多变量分析中，增加旅行疾病风险的因素包括 IBD 频繁发作（OR，1.9；95% CI，1.1-3.4；P=.02）和既往 IBD 相关住院治疗（OR，3.5；95% CI，1.3-9.3；P=.01）；旅行前 3 个月内病情缓解可降低患病风险（OR，0.3；95% CI，0.16-0.5；P
BACKGROUND & AIMS: There are few data on risk of travel for patients with inflammatory bowel disease (IBD). We assessed rates of illness while traveling among patients with IBD. METHODS: We performed a retrospective, case-controlled study of illnesses among 222 patients with IBD and 224 healthy individuals (controls) during 1099 total trips. Data were retrieved by structured questionnaires, personal interviews, and chart review. RESULTS: Participants had 142 episodes of illness during the trips; 92% were enteric disease. An episode of illness occurred during 79/523 (15.1%) trips made by patients with IBD compared with 63/576 (10.9%) trips made by controls (odds ratio [OR], 1.44; 95% confidence interval [CI], 1.01-2.0; P=.04). However, this difference was mostly attributable to the increased incidence of illness among IBD patients traveling in industrialized countries. In contrast, the rate of illness among travelers to developing countries was similar among patients with IBD and controls (34/200, 17% vs 52/243, 21% of trips, respectively; P=.24). Moreover, numerically more controls that traveled to the tropics developed illness than travelers with IBD (43/135 vs 23/97, respectively; P=.18). In multivariate analysis, factors that increased risk for travel illness included frequent flares of IBD (OR, 1.9; 95% CI, 1.1-3.4; P=.02) and prior IBD-related hospitalizations (OR, 3.5; 95% CI, 1.3-9.3; P=.01); remission within 3 months before traveling reduced the risk for illness (OR, 0.3; 95% CI, 0.16-0.5; P