Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins.
Regulation of Heme Synthesis by Mitochondrial Homeostasis Proteins.
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DOI：
10.3389/fcell.2022.895521
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
血红素在各种生命必需过程中起着核心作用，这些过程从无处不在的管家途径（如呼吸）到高度细胞特异性的途径（如血红蛋白的氧运输）。血红素合成及其利用的调节是高度调节的和细胞特异性的。在这篇综述中，我们试图描述血红素合成机制是如何通过线粒体内稳态来调节的，以将血红素合成与其利用和细胞的代谢要求结合起来。我们重点讨论了管家蛋白对线粒体血红素合成酶的调节、血红素中间体的转运以及大分子复合物形成和线粒体代谢对血红素合成的调节。最近发现的机制进行了讨论的背景下，他们被确定的模式生物，而更多的既定工作进行了讨论，在技术进步。
Heme plays a central role in diverse, life-essential processes that range from ubiquitous, housekeeping pathways such as respiration, to highly cell-specific ones such as oxygen transport by hemoglobin. The regulation of heme synthesis and its utilization is highly regulated and cell-specific. In this review, we have attempted to describe how the heme synthesis machinery is regulated by mitochondrial homeostasis as a means of coupling heme synthesis to its utilization and to the metabolic requirements of the cell. We have focused on discussing the regulation of mitochondrial heme synthesis enzymes by housekeeping proteins, transport of heme intermediates, and regulation of heme synthesis by macromolecular complex formation and mitochondrial metabolism. Recently discovered mechanisms are discussed in the context of the model organisms in which they were identified, while more established work is discussed in light of technological advancements.
影响因子：
7.5
作者：
Farrell CP;Nicolas G;Desnick RJ;Parker CJ;Lamoril J;Gouya L;Karim Z;Tchernitchko D;Chan B;Puy H;Phillips JD
通讯作者：
Phillips JD