Changes in IgE sensitization and total IgE levels over 20 years of follow-up.
Changes in IgE sensitization and total IgE levels over 20 years of follow-up.
复制标题
DOI：
10.1016/j.jaci.2015.09.037
复制
发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Jarvis DL
中科院分区：
文献类型：
--
作者：
Amaral AFS;Newson RB;Abramson MJ;Antó JM;Bono R;Corsico AG;de Marco R;Demoly P;Forsberg B;Gislason T;Heinrich J;Huerta I;Janson C;Jõgi R;Kim JL;Maldonado J;Martinez-Moratalla Rovira J;Neukirch C;Nowak D;Pin I;Probst-Hensch N;Raherison-Semjen C;Svanes C;Urrutia Landa I;van Ree R;Versteeg SA;Weyler J;Zock JP;Burney PGJ;Jarvis DL
横断面研究报告了老年人中致敏的患病率较低，但很少有纵向研究研究探讨这是老龄化还是出生年份的队列效应。我们试图评估一组欧洲成年人年龄超过20岁时致敏性和总IgE水平的变化。在欧洲共同体呼吸健康调查的25个中心的3206名成年人中，测定了20年内3次常见空气过敏原（屋尘螨、猫和草）的血清特异性IgE水平和总IgE水平。通过使用回归分析（针对实验室设备的潜在差异进行校正）和使用逆抽样概率权重（考虑无应答）分析致敏和总IgE水平的变化。在20年的随访中，对3种过敏原中至少1种过敏的患病率从29.4%降至24.8%（−4.6%; 95%CI，−7.0%至−2.1%）。对屋尘螨（-4.3%; 95%CI，-6.0%至-2.6%）和猫（-2.1%; 95%CI，-3.6%至-0.7%）的致敏率下降幅度大于对草的致敏率（-0.6%; 95%CI，-2.5%至1.3%）。对屋尘螨和猫的致敏性在出生年份之间没有差异，但对草的致敏性在最近的人群中最普遍。总体而言，在所有出生年份队列中，所有年龄组的总IgE水平均显著降低（几何平均值比，0.63; 95% CI，0.58-0.68）。20岁以后，年龄增长与较低的致敏水平有关，特别是对屋尘螨和猫。
Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect. We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period. Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse. Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (−4.6%; 95% CI, −7.0% to −2.1%). The prevalence of sensitization to house dust mite (−4.3%; 95% CI, −6.0% to −2.6%) and cat (−2.1%; 95% CI, −3.6% to −0.7%) decreased more than sensitization to grass (−0.6%; 95% CI, −2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts. Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.