Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: Study of women's health across the nation
Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: Study of women's health across the nation
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DOI：
10.2105/ajph.2005.066936
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发表时间：
2006-07-01
影响因子：
12.7
通讯作者：
Matthews, Karen
中科院分区：
文献类型：
--
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
目标。我们调查了一项全国性研究中入选的妇女在围绝经期的血管舒缩症状报告或症状报告的变化模式是否因种族/民族而异。我们还试图确定种族/民族差异是否可以用社会人口统计学、健康或生活方式因素来解释。在1996年至2002年期间，我们跟踪了3198名参加了全国妇女健康研究的妇女。我们使用纵向多元logistic回归分析血管舒缩症状报告的频率。非裔美国人的血管舒缩症状报告率最高（校正优势比[OR] = 1.63； 95%可信区间[CI] = 1.21, 2.20）。绝经后期与血管舒张症状的相关性最强（调整后OR=6.64; 95% CI = 4.80, 9.20）。其他危险因素包括年龄（调整后的OR = 1.17; 95% CI = 1.13, 1.21）、大学学历以下（调整后的OR = 1.91; 95% CI = 1.40, 2.61）、体重指数增加（调整后的OR = 1.03 /单位增加；95% CI = 1.01, 1.04）、吸烟（调整后的OR = 1.63; 95% CI = 1.25, 2.12）和基线时的焦虑症状（调整后的OR = 3.10; 95% CI = 2.33, 4.12）。在评估的危险因素中，血管舒缩症状与绝经状态的关系最为密切。调整协变量后，所有种族/族裔群体在围绝经晚期报告的症状最多，在绝经后报告的症状也几乎相同。
Objectives. We investigated whether vasomotor symptom reporting or patterns of change in symptom reporting over the perimenopausal transition among women enrolled in a national study differed according to race/ethnicity. We also sought to determine whether racial/ethnic differences were explained by socio-demographic, health, or lifestyle factors.Methods. We followed 3198 women enrolled in the Study of Women's Health Across the Nation during 1996 through 2002. We analyzed frequency of vasomotor symptom reporting using longitudinal multiple logistic regressions.Results. Rates of Vasomotor symptom reporting were highest among African Americans (adjusted odds ratio [OR] = 1.63; 95% confidence interval [CI] = 1.21, 2.20). The transition to late perimenopause exhibited the strongest association with vasomotor symptoms (adjusted OR=6.64; 95% CI = 4.80, 9.20). Other risk factors were age (adjusted OR = 1.17; 95% CI = 1.13, 1.21), having less than a college education (adjusted OR = 1.91; 95% CI = 1.40, 2.61), increasing body mass index (adjusted OR = 1.03 per unit of increase; 95% CI = 1.01, 1.04), smoking (adjusted OR = 1.63; 95% CI = 1.25, 2.12), and anxiety symptoms at baseline (adjusted OR = 3.10; 95% CI = 2.33, 4.12).Conclusions. Among the risk factors assessed, vasomotor symptoms were most strongly associated with menopausal status. After adjustment for covariates, symptoms were reported most often in all racial/ethnic groups in late perimenopause and nearly as often in postmenopause.