Gastrointestinal Myoelectric Measurements via Simultaneous External and Internal Electrodes in Pigs.
Gastrointestinal Myoelectric Measurements via Simultaneous External and Internal Electrodes in Pigs.
复制标题
通过同步外部和内部电极对猪进行胃肠道肌电测量。
DOI：
10.1016/j.jss.2022.05.012
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Dunn,JamesCY
中科院分区：
文献类型：
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作者：
Salimi-Jazi,Fereshteh;Thomas,Anne-Laure;Rafeeqi,Talha;Diyaolu,Modupeola;Wood,LaurenSY;Axelrod,Steve;Navalgund,Anand;Axelrod,Lindsay;Dunn,JamesCY
前言目前，没有准确的非侵入性测量系统来诊断胃肠道（GI）动力障碍。无线皮肤贴片已经被引入以提供GI肌电活动的准确的非侵入性测量，这对于开发神经刺激设备以治疗GI运动障碍是必不可少的。本研究的目的是比较外部和内部的电信号测量在门诊pigs.MethodsYucatan猪进行放置内部电极的胃，小肠，结肠。导丝穿过腹壁。信号由无线接收器收集。将四个外部贴片放置在腹部皮肤上以同时记录信号。猪保持6 d，而传感器连续记录的数据从两个system.ResultsInternal传感器检测到丰富的信号从每个器官。胃有一个主导频率，范围从4到4.5 cpm，偶尔更高的频率在2，3和4倍。小肠信号的初级能量在12-15 cpm范围内。结肠信号主要在4- 6cpm区域中显示主导宽峰。外部皮肤贴片检测到了内部电极测量的活动的很大一部分。一个明确的一致性的频谱之间的内部和外部readings.ConclusionsInternally测量的肌电信号证实了不同的模式的胃，小肠和结肠的节奏活动。皮肤贴片提供了GI肌电测量，其频率范围可用于诊断和治疗动力障碍。
IntroductionCurrently, there is no accurate noninvasive measurement system to diagnose gastrointestinal (GI) motility disorders. Wireless skin patches have been introduced to provide an accurate noninvasive measurement of GI myoelectric activity which is essential for developing neuro-stimulation devices to treat GI motility disorders. The aim of this study is to compare the external and internal electrical signal measurements in ambulatory pigs.MethodsYucatan pigs underwent placement of internal electrodes on the stomach, small intestine, and colon. Wires were brought through the abdominal wall. Signals were collected by a wireless receptor. Four external patches were placed on the abdominal skin to record the signals simultaneously. Pigs were kept for 6 d while the sensors were continuously recording the data from both systems.ResultsInternal sensors detected rich signals from each organ. The stomach had a dominant frequency that ranged from 4 to 4.5 cpm, with occasional higher frequencies at 2, 3 and 4 times that. Small intestine signals had their primary energy in the 12-15 cpm range. Colon signals primarily displayed a dominant broad peak in the 4-6 cpm region. External skin patches detected a substantial fraction of the activities measured by the internal electrodes. A clear congruence in the frequency spectrum was observed between the internal and external readings.ConclusionsInternally measured myoelectrical signals confirmed different patterns of rhythmic activity of the stomach, small intestine, and colon. Skin patches provided GI myoelectric measurement with a range of frequencies that could be useful in the diagnosis and treatment of motility disorders.