Mucin production and mucous cell metaplasia in otitis media.
Mucin production and mucous cell metaplasia in otitis media.
复制标题
DOI：
10.1155/2012/745325
复制
发表时间：
2012
影响因子：
--
通讯作者：
Kerschner JE
中科院分区：
文献类型：
--
作者：
Lin J;Caye-Thomasen P;Tono T;Zhang QA;Nakamura Y;Feng L;Huang J;Ye S;Hu X;Kerschner JE
中耳炎伴粘液渗出是中耳炎的一种亚型，其特征是中耳裂内粘液细胞化生/增生和中耳腔内粘稠液体积聚，常导致幼儿慢性中耳炎。粘液渗出型中耳炎的发生与多种因素有关，尤其是中耳细菌感染和咽鼓管功能障碍导致的粘液分泌障碍。在这篇综述中，我们将集中在这种疾病的几个方面，通过分析细胞和分子的事件，如粘蛋白的生产和粘液细胞分化的中耳粘膜OM。此外，传染性病原体，粘蛋白生产触发器，和相关的信号通路将进行讨论。
Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed.