Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan
Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan
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DOI：
10.1007/s10156-011-0225-2
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发表时间：
2011-10-01
影响因子：
2.2
通讯作者：
Yamamoto, Yoshimasa
中科院分区：
文献类型：
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作者：
Luvsansharav, Ulzii-Orshikh;Hirai, Itaru;Yamamoto, Yoshimasa
在日本，医院环境中超广谱 β-内酰胺酶 (ESBL) 产生者的流行率呈上升趋势。在本研究中，我们调查了健康成年人粪便中产 ESBL 肠杆菌科细菌的携带情况。收集粪便样本用于产 ESBL 肠杆菌科细菌的表型和基因型鉴定。通过表型鉴定，我们发现ESBL产生者的患病率为6.4%，其中92.9%拥有bla(CTX-M)基因。在产 CTX-M ESBL 的肠杆菌科细菌中，我们鉴定出 11 株大肠埃希菌和 2 株肺炎克雷伯菌。研究结果表明，在日本，健康人粪便中携带的 CTX-M 型 ESBL 生产者正在迅速增加。这可能是产 ESBL 细菌在医院内传播增加的原因之一。
In Japan, the prevalence of extended-spectrum beta-lactamase (ESBL) producers in hospital settings has shown an increasing trend. In the present study, we investigated the prevalence of the fecal carriage of ESBL-producing Enterobacteriaceae among healthy adults. Stool samples were collected for the phenotypic and genotypic identification of ESBL-producing Enterobacteriaceae. We found the prevalence of ESBL producers to be 6.4% by phenotypic identification, and 92.9% of them possessed the bla(CTX-M) gene. Among the CTX-M ESBL-producing Enterobacteriaceae, we identified 11 Escherichia coli and 2 Klebsiella pneumonia strains. The findings suggest that the fecal carriage of CTX-M-type ESBL producers by healthy people is rapidly increasing in Japan. This may be one of the causes of the increased spread of ESBL-producing bacteria in hospitals.