Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon.
Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon.
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结肠腺癌中癌胚抗原和血型物质的分布。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
Joseph C. Eggleston
中科院分区：
文献类型：
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作者：
Elizabeth L. Wiley;Geoffrey Mendelsohn;Joseph C. Eggleston
本文应用免疫过氧化物酶技术对41例结肠腺癌和15例转移或复发癌的癌胚抗原（CEA）和人血型物质（BGS）进行了定位。10例原发性肿瘤（24%）对两种抗原均呈强阳性，12例（29%）仅对BGS呈阳性，11例（27%）仅对CEA呈阳性，8例（20%）仅含有微量的任何一种抗原。除了少数例外，单个肿瘤细胞含有CEA，BGS或两者都不含，但不是两者都含有。BGS阳性的左半结肠癌与转移频率较低相关（p <0.01）;缺乏CEA和BGS的肿瘤比含有其中一种或两种抗原的肿瘤转移更频繁（p <0.01）。在右半结肠肿瘤中，抗原含量和转移频率之间没有显著相关性。在3例病例中，复发或转移性肿瘤的发生与BGS阳性丧失相关。这些数据表明，BGS和CEA的免疫组化研究可能是有价值的估计某些结肠癌的临床行为。
Immunoperoxidase techniques were used to localize carcinoembryonic antigens (CEA) and human blood group substances (BGS) in 41 adenocarcinomas of the colon and 15 metastases or recurrences of these tumors. Ten primary tumors (24 per cent) were strongly positive for both antigens, 12 (29 per cent) were positive for BGS only, 11 (27 per cent) were positive for CEA only, and eight (20 per cent) contained only microscopic amounts of either. With few exceptions, individual tumor cells contained either CEA, BGS, or neither, but not both. Cancers of the left colon which were positive for BGS were associated with a lower frequency of metastases than were those without BGS (p less than 0.01); tumors lacking both CEA and BGS metastasized more frequently than those tumors containing either or both antigens (p less than 0.01). In tumors of the right colon, there was no significant correlation between antigen content and frequency of metastases. In three cases, the development of recurrent or metastatic tumor was associated with a loss of BGS positivity. The data suggest that immunohistochemical studies of BGS and CEA may be of value in estimating the clinical behavior of certain colon carcinomas.