Human immunodeficiency virus, herpes virus infections, and pulmonary vascular disease.
Human immunodeficiency virus, herpes virus infections, and pulmonary vascular disease.
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DOI：
10.4103/2045-8932.109955
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发表时间：
2013-01
影响因子：
2.6
通讯作者：
Almodovar S
中科院分区：
文献类型：
--
作者：
Flores SC;Almodovar S
以下最先进的研讨会是2012年6月在科罗拉多州阿斯彭举行的关于肺高压和血管疾病的阿斯彭肺会议的一部分。本文将总结这次讲座，并介绍人类免疫缺陷病毒-nef嵌合病毒粒子感染的非人类灵长类动物模型的结果，以及HIV-1 nef基因的多态可能驱动导致旺盛炎症和内皮细胞(EC)功能异常的免疫反应的想法。我们将介绍从初级HIV nef分离株收集的数据，在那里我们测试了这些多态的生物学后果，以及它们在人类群体中的存在如何预测患者有患这种疾病的风险。在这篇文章中，我们还讨论了免疫系统调节失调，与病毒感染一起，如何导致肺动脉高压(PAH)。自身免疫性疾病和一些病毒都与免疫系统缺陷有关，主要是调节性T细胞的功能缺陷。这些T细胞缺陷可能是丛状病变形成的常见途径。不管病毒可能通过什么途径导致PAH，重要的是要认识到它们在这种罕见疾病中的作用。
The following state-of-the-art seminar was delivered as part of the Aspen Lung Conference on Pulmonary Hypertension and Vascular Diseases held in Aspen, Colorado in June 2012. This paper will summarize the lecture and present results from a nonhuman primate model of infection with Simian (Human) Immunodeficiency Virus - nef chimeric virions as well as the idea that polymorphisms in the HIV-1 nef gene may be driving the immune response that results in exuberant inflammation and aberrant endothelial cell (EC) function. We will present data gathered from primary HIV nef isolates where we tested the biological consequences of these polymorphisms and how their presence in human populations may predict patients at risk for developing this disease. In this article, we also discuss how a dysregulated immune system, in conjunction with a viral infection, could contribute to pulmonary arterial hypertension (PAH). Both autoimmune diseases and some viruses are associated with defects in the immune system, primarily in the function of regulatory T cells. These T-cell defects may be a common pathway in the formation of plexiform lesions. Regardless of the route by which viruses may lead to PAH, it is important to recognize their role in this rare disease.
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DOI：
10.1164/rccm.201003-0491oc
发表时间：
2010-11-01
影响因子：
24.7
作者：
Aldred, Micheala A.;Comhair, Suzy A.;Coldren, Christopher D.
通讯作者：
Coldren, Christopher D.
影响因子：
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作者：
Carter, Chris J.
通讯作者：
Carter, Chris J.
影响因子：
158.5
作者：
Cool, CD;Rai, PR;Voelkel, NF
通讯作者：
Voelkel, NF
影响因子：
3.8
作者：
Opravil, Milos;Sereni, Daniel
通讯作者：
Sereni, Daniel
影响因子：
5.4
作者：
Contreras-Galindo, Rafael;Kaplan, Mark H.;Markovitz, David M.
通讯作者：
Markovitz, David M.