An Examination of the Role of Socioeconomic Status in the Relationship between Depression and Prostate Cancer Survivorship in a Population-Based Sample of Men from Atlantic Canada
An Examination of the Role of Socioeconomic Status in the Relationship between Depression and Prostate Cancer Survivorship in a Population-Based Sample of Men from Atlantic Canada
复制标题
DOI：
10.1159/000512444
复制
发表时间：
2021-01-22
期刊：
影响因子：
3.5
通讯作者：
Sweeney, Ellen
中科院分区：
文献类型：
--
作者：
Ilie, Gabriela;Rutledge, Robert;Sweeney, Ellen
目的：前列腺癌和皮肤癌是男性中最常见的癌症形式之一，与其他更具侵袭性的癌症形式相比，它们的生存率较高。最近的研究表明，与没有前列腺癌病史的男性相比，有前列腺癌病史的男性患抑郁症的几率更高。在这里，我们扩展了以前的研究结果，并在加拿大大西洋地区的男性人群样本中研究了社会经济地位在抑郁症和癌症生存状态之间的关系中的作用。方法：对大西洋PATH研究2009-2015年调查周期中6585名49-69岁男性参与者的子样本进行横断面分析。主要结果是使用患者健康问卷（PHQ-9）筛查轻度、中度或重度抑郁症呈阳性。主要的预测变量是癌症生存状态（一生中是否有前列腺癌、皮肤癌、前列腺癌或皮肤癌以外的癌症形式，或一生中没有癌症诊断）。协变量包括年龄、教育程度、婚姻状况、家庭收入、省份、种族、合并症和生存时间。结果：该样本中估计有14.7%的男性筛查为轻度、中度或重度抑郁症阳性。有前列腺癌病史的男性抑郁筛查呈阳性的可能性是有其他癌症病史的男性的2.60倍（95% CI: 1.02, 6.65）。对于家庭收入低的前列腺癌或皮肤癌幸存者，与有其他癌症病史和家庭收入高的男性相比，其抑郁筛查呈阳性的比值比为10.23 （95% CI: 2.82, 37.49）或4.00 （95% CI: 1.20, 13.34）。结论：这些结果扩展了目前前列腺癌幸存者与抑郁症之间的关联的证据，与从未有过癌症诊断史的男性相比，前列腺癌幸存者与任何其他形式的癌症幸存者相比仍然存在这种关联，并进一步表明这种关联受到家庭收入的调节。研究结果强调了在癌症治疗过程中为前列腺癌幸存者提供心理健康检查和支持的重要性，尤其是那些家庭收入较低的人。
Objective: Prostate and skin cancer are among the most prevalent forms of cancer among men and have favorable survival rates compared to other, more aggressive forms of cancers. Recent studies have shown that the odds of depression among men with a lifetime history of prostate cancer are higher compared to men without a lifetime history of prostate cancer. Here we extend previous findings and examine the role of socioeconomic status in the relationship between depression and cancer survivorship status in a population-based sample of men from Atlantic Canada. Methods: A cross-sectional analysis was conducted on a subsample of 6,585 male participants aged 49-69 years from the 2009-2015 survey cycle of the Atlantic PATH study. The primary outcome was screening positive for mild, moderate or severe depression using the Patient Health Questionnaire (PHQ-9). The main predictor variable was cancer survivorship status (the presence of a lifetime history of prostate cancer, skin cancer, forms of cancer other than prostate or skin cancer, or absence of a lifetime cancer diagnosis). Covariates included age, education, marital status, household income, province, ethnicity, comorbidity, and survivorship time. Results: An estimated 14.7% of men in this sample screened positive for mild, moderate or severe depression. Men with a history of prostate cancer were 2.60 (95% CI: 1.02, 6.65) times more likely to screen positive for depression than men with a history of any other form of cancer. The odds ratios were 10.23 (95% CI: 2.82, 37.49) or 4.00 (95% CI: 1.20, 13.34) times higher for survivors of prostate or skin cancer who reported a low household income to screen positive for depression compared to men with a history of any other form of cancer and high household income. Conclusions: These results extend current evidence of the association between prostate cancer survivorship and depression compared with men who never had a history of cancer diagnosis by indicating that this association still stands when the survivors of prostate cancer are compared to survivors of any other form of cancer, and further indicates that this association is moderated by household income. The findings highlight the importance of delivering mental health screening and support to prostate cancer survivors during the cancer journey, especially those with low household incomes.