Associations of Physical Activity and Lactation Duration With Cardiometabolic Risk Factors: The CARDIA Study.
Associations of Physical Activity and Lactation Duration With Cardiometabolic Risk Factors: The CARDIA Study.
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体力活动和哺乳时间与心脏代谢危险因素的关联：CARDIA 研究。
DOI：
10.1016/j.jacadv.2023.100378
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Gunderson,EricaP
中科院分区：
文献类型：
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作者：
Lane,Abbi;Whitaker,KaraM;Tahir,Muna;BaroneGibbs,Bethany;Catov,Janet;Carnethon,Mercedes;Gunderson,EricaP
体育活动（PA）和哺乳有益于心脏代谢健康。目的本研究的目的是描述PA和哺乳期与心脏代谢风险的联合关系。方法：在青年人冠状动脉风险发展研究中，我们对黑人和白人分娩妇女的一生泌乳量进行平均。根据PA （- PA: <中位数；+PA:≥中位数）和哺乳期（- L: <3个月，+L:≥3个月）进行分类。参与者被分配到4组：−PA/−L，−PA/+L， +PA/−L和+PA/+L（最有利）。30岁时的心脏代谢危险因素被标准化为风险评分。我们使用线性回归评估了风险因素和风险评分之间的相关性。协变量包括年龄、种族、研究中心、胎次、教育程度、吸烟、用药、饮酒、基线体重指数和饮食质量。结果中位PA为256个运动单位，54%报告哺乳期≥3个月。在1068名参与者中，303人属于- PA/ - L， 231人属于- PA/+L， 184人属于+PA/ - L， 350人属于+PA/+L。+PA/+L的参与者年龄较大，受教育时间更长，体重指数较低，体重增加较少，与- PA/ - L的参与者相比，黑人的可能性较小。风险评分不同类别之间除了−PA / + L和+ PA /−L (P = 0.08):−PA /−L: 0.23 + /−0.04−PA / + L: 0.08 + /−0.04 + PA /−L: + /−0.02−0.05,+ PA / + L:−0.23 + /−0.03。调整后，+PA/+L与较低/较好的风险评分相关（β = - 0.15, 95% CI: - 0.25至- 0.04）。结论成年期PA高于平均水平并哺乳期≥3个月与较低的风险评分相关。有任何一种行为的参与者比没有任何行为的参与者风险更低。达到这些水平的行为可能会降低产妇的心脏代谢风险。
BackgroundPhysical activity (PA) and lactation benefit cardiometabolic health.ObjectivesThe purpose of this study was to describe the joint associations of PA and lactation with cardiometabolic risk.MethodsWe averaged PA across exams and summed lifetime lactation in Black and White parous women in the Coronary Artery Risk Development in Young Adults Study. Categories were created for PA (−PA: <median; +PA: ≥median) and lactation (−L: <3 months, +L: ≥3 months). Participants were assigned to one of 4 groups: −PA/−L, −PA/+L, +PA/−L, and +PA/+L (most favorable). Cardiometabolic risk factors at the year 30 exam were standardized into a risk score. We evaluated associations of groups with risk factors and risk score using linear regression. Covariates included age, race, study center, parity, education, smoking, medication use, alcohol consumption, and baseline body mass index, and diet quality.ResultsThe median PA was 256 exercise units and 54% reported lactation duration of ≥3 months. Of 1,068 participants, 303 were in the −PA/−L category, 231 in −PA/+L, 184 in +PA/−L, and 350 in +PA/+L. +PA/+L participants were older, had more years of education, lower body mass index, gained less weight, and less likely to be Black vs −PA/−L participants. Risk scores differed between categories except −PA/+L and +PA/−L (P= 0.08): −PA/−L: 0.23+/−0.04, −PA/+L: 0.08+/−0.04, +PA/−L: −0.02+/−0.05, and +PA/+L: −0.23+/−0.03. After adjustment, +PA/+L was associated with a lower/better risk score (β = −0.15, 95% CI: −0.25 to −0.04).ConclusionsAbove average PA throughout adulthood combined with ≥3 months of lactation was associated with lower risk scores. Participants with either behavior had lower risk vs those with neither behavior. Attaining these levels of behaviors may reduce cardiometabolic risk in parous women.