Enzymatic Machinery of Ubiquitin and Ubiquitin-Like Modification Systems in Chondrocyte Homeostasis and Osteoarthritis.
Enzymatic Machinery of Ubiquitin and Ubiquitin-Like Modification Systems in Chondrocyte Homeostasis and Osteoarthritis.
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DOI：
10.1007/s11926-021-01022-w
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发表时间：
2021-07-03
影响因子：
5
通讯作者：
Yang T
中科院分区：
文献类型：
--
作者：
Liu Y;Molchanov V;Yang T
到目前为止，大量的信息有关的泛素化（Ub）和泛素化样（Ubl）修饰相关的机制已被报道的背景下，骨骼细胞的稳态和疾病。在这篇综述中，我们主要集中在最近的研究结果的贡献，酶机制，直接添加或删除Ub和Ubl修饰的蛋白质目标在软骨细胞的稳态和骨关节炎（OA）的发展。促进关节软骨细胞稳态的机制对于维持关节的完整性以防止骨关节炎的发展至关重要。关节软骨细胞是不断产生和重塑软骨基质的有丝分裂后细胞。此外，软骨细胞的长寿命使它们容易受到累积的细胞损伤。Ub和进化上保守的Ubl修饰，如SUMO化、ATG化和UFM化，在促进软骨细胞稳态中发挥重要作用，包括调节细胞信号传导和蛋白质稳定性，解决细胞应激和炎症，以及维持软骨细胞的分化和存活。发现Ub/Ubl修饰机制的新组分/功能可能为治疗OA提供新的药物靶点。
To date, a vast amount of information regarding ubiquitination (Ub) and ubiquitylation-like (Ubl) modification–related mechanisms has been reported in the context of skeletal cell homeostasis and diseases. In this review, we mainly focus on recent findings regarding the contribution of enzymatic machinery that directly adds or removes Ub and Ubl modifications from protein targets in chondrocyte homeostasis and osteoarthritis (OA) development. Mechanisms that promote homeostasis of articular chondrocytes are crucial for maintaining the integrity of articular joints to prevent osteoarthritis development. Articular chondrocytes are postmitotic cells that continuously produce and remodel cartilage matrix. In addition, the long lifespan of chondrocytes makes them susceptible to accumulating cellular damage. Ub and the evolutionarily conserved Ubl modifications, such as SUMOylation, ATGylation, and UFMylation, play important roles in promoting chondrocyte homeostasis, including regulating cell signaling and protein stability, resolving cellular stresses and inflammation, and maintaining differentiation and survival of chondrocytes. Uncovering new components/functions of Ub/Ubl modification machinery may provide novel drug targets to treat OA.
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