Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
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DOI：
10.1016/j.bbr.2006.07.004
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发表时间：
2006-11-01
影响因子：
2.7
通讯作者：
Whishaw, Ian Q.
中科院分区：
文献类型：
--
作者：
Field, Evelyn F.;Metz, Gerlinde A.;Whishaw, Ian Q.
对人类帕金森病发病、进展和症状的性别差异的研究得出了不同的结果。在这项研究中，我们使用了单侧6-羟基多巴胺（6-OHDA）损伤的帕金森病动物模型，以解决是否有性别差异的组成中使用的运动在垂直探索在一个封闭的圆柱体。酪氨酸羟化酶染色和阿扑吗啡诱导的旋转用于确认病变程度。垂直回合的发生频率或垂直花费的平均时间没有性别差异或损伤效应。在垂直探索期间，雄性和雌性6-OHDA动物在前肢使用方面表现出相同的损伤。6-然而，与6-OHDA雌性相比，OHDA雄性的后肢使用显著减少。后肢步方向的分析表明，虽然假女性更有可能向前一步，假男性更有可能在垂直回合后退。6-OHDA动物中不再存在这种性别差异。最后，6-OHDA雄性动物在垂直回合期间比任何其他条件下的动物更有可能将其背部表面与圆柱体壁接触以保持直立姿势。这些结果表明，使用一个封闭的圆柱体任务是适当的运动学分析的性别差异的垂直行为，并表明，有性别差异的运动行为在人类帕金森氏病的动物模型。(c)2006 Elsevier B. V.保留所有权利。
The study of sex differences in the onset, progression and symptoms of Parkinson's disease, in humans, has led to mixed results. In this study, we used a unilateral 6-hydroxydopamine (6-OHDA) lesion animal model of Parkinson's disease, to address whether there are sex differences in the composition of the movements used during vertical exploration within a confined cylinder. Tyrosine hydroxylase staining and apomorphine induced rotation were used to confirm lesion magnitude. There were no sex differences or lesion effects in the frequency of occurrence of a vertical bout or the average time spent vertical. Both male and female 6-OHDA animals exhibited equal impairments in the use of the forelimbs during vertical exploration. 6-OHDA males, as compared to 6-OHDA females, however, had a significant reduction in the use of their hindlimbs. An analysis of hindlimb step direction revealed that while sham females were more likely to step forward, sham males were more likely to step backwards during a vertical bout. This sex difference was no longer present in the 6-OHDA animals. Finally, 6-OHDA males were significantly more likely to place their dorsal surface in contact with the wall of the cylinder to maintain an upright posture during a vertical bout than animals in any other condition. These results demonstrate that the use of a confined cylinder task is appropriate for the kinematic analysis of sex differences in vertical behaviour and show that there are sex differences in motor behaviour in an animal model of human Parkinson's disease. (c) 2006 Elsevier B.V. All rights reserved.