The Maternal Infant Microbiome: Considerations for Labor and Birth.
The Maternal Infant Microbiome: Considerations for Labor and Birth.
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DOI：
10.1097/nmc.0000000000000373
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Carlson NS
中科院分区：
文献类型：
--
作者：
Dunn AB;Jordan S;Baker BJ;Carlson NS
人类微生物组在维持健康方面发挥作用，但也被认为会减弱和/或加剧不利母婴健康结果的风险因素。微生物组的发育始于子宫，然而与分娩和出生环境相关的因素已被证明会影响新生儿微生物组的初始定植过程。这种“播种”或将微生物从母亲转移到新生儿身上，可能是一种早期接种过程，对新生儿的长期健康结果具有影响。研究表明，与剖腹产出生的新生儿相比，顺产出生的新生儿的微生物组谱存在明显差异。抗生素暴露已被证明会改变妇女的微生物特征，并可能影响其新生儿的肠道微生物特征。考虑到第一个主要的微生物定植发生在分娩时，分娩和分娩护士必须意识到在分娩和分娩过程中可能改变微生物组组成的因素。在分娩和分娩过程中，分娩和分娩环境中可能影响妇女和新生儿微生物群的各种活动和因素的影响（例如分娩路线、抗生素使用、护理程序）被提出，重点是分娩护士的作用和护理活动对这一过程的潜在影响。
The human microbiome plays a role in maintaining health, but is also thought to attenuate and/or exacerbate risk factors for adverse maternal-child health outcomes. The development of the microbiome begins in utero, however factors related to the labor and birth environment have been shown to influence the initial colonization process of the newborn microbiome. This “seeding” or transfer of microbes from the mother to newborn may serve as an early inoculation process with implications for the long-term health outcomes of newborns. Studies have shown that there are distinct differences in the microbiome profiles of newborns born vaginally compared to those born by cesarean. Antibiotic exposure has been shown to alter the microbial profiles of women and may influence the gut microbial profiles of their newborns. Considering that the first major microbial colonization occurs at birth, it is essential that labor and birth nurses be aware of factors that may alter the composition of the microbiome during the labor and birth process. The implications of various activities and factors unique to the labor and birth environment that may influence the microbiome of women and newborns during the labor and birth process (e.g. route of birth, antibiotic use, nursing procedures) are presented with a focus on the role of labor nurses and the potential influence of nursing activities on this process.