RAPID SWITCHING OF ION CURRENT IN NARROW PORES - IMPLICATIONS FOR BIOLOGICAL ION CHANNELS
RAPID SWITCHING OF ION CURRENT IN NARROW PORES - IMPLICATIONS FOR BIOLOGICAL ION CHANNELS
复制标题
DOI：
10.1098/rspb.1993.0064
复制
发表时间：
1993-06-22
影响因子：
4.7
通讯作者：
PASTERNAK, CA
中科院分区：
文献类型：
--
作者：
LEV, AA;KORCHEV, YE;PASTERNAK, CA
离子流过由聚对苯二甲酸乙二醇酯制成的纯合成过滤器，该过滤器已被蚀刻以产生窄孔，显示出：（i）高导电状态和低导电状态之间的快速转变;（ii）离子流的选择性;以及（iii）二价阳离子和质子的抑制。这些特征类似于许多生物离子通道所显示的特征。我们解释我们的结果中的特殊性质的离子电导在界面上，可以观察到的体积电导的贡献是最小的。
Ions flowing through purely synthetic filters made of polyethylene terephthalate which have been etched to produce narrow pores show: (i) rapid transitions between a high-conducting and a low-conducting state; (ii) selectivity of ion flow; and (iii) inhibition by divalent cations and protons. These features resemble those displayed by many biological ion channels. We interpret our results in terms of the special properties of ion conductance at an interface that may be observed whenever the contribution of bulk conductance is minimal.