The role of the human ventral striatum and the medial orbitofrontal cortex in the representation of reward magnitude - An activation likelihood estimation meta-analysis of neuroimaging studies of passive reward expectancy and outcome processing
The role of the human ventral striatum and the medial orbitofrontal cortex in the representation of reward magnitude - An activation likelihood estimation meta-analysis of neuroimaging studies of passive reward expectancy and outcome processing
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DOI：
10.1016/j.neuropsychologia.2012.02.007
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发表时间：
2012-06-01
期刊：
影响因子：
2.6
通讯作者：
Gruber, Oliver
中科院分区：
文献类型：
--
作者：
Diekhof, Esther Kristina;Kaps, Lisa;Gruber, Oliver
奖励最大化是每个生物体的核心动机。在人类中，有几个大脑区域被认为与奖励量级的表征有关。然而，尚不清楚相同的大脑区域是否在奖励预测及其消费中始终发挥作用。在这项研究中，我们使用基于坐标的激活似然估计（ALE）元分析来确定腹侧纹状体（vSTR）和内侧眶额皮质（mOFC/VMPFC）在一般奖励表征，特别是奖励量级表征中的各自作用。具体而言，我们想要评估在被动预期和消费奖励过程中大脑区域激活的共性和差异。对过去十年的神经影像数据进行的两项独立元分析揭示了vSTR在奖励预期和消费中的一般作用。尤其是当消费的奖励意外出现或不确定时更是如此。相比之下，对于mOFC/VMPFC，目前的元分析数据表明其在奖励消费中具有相当特定的功能，而非在被动预期中。重要的是，当仅考虑比较不同奖励量级的坐标时，vSTR和mOFC/VMPFC的相同部分在各项研究中显示出一致的反应，尽管一致性区域在局部上更为局限。这些元分析数据表明，vSTR可能参与显著奖励的预测和消费，并且可能对不同的奖励量级也敏感，而mOFC/VMPFC可能在奖励接收过程中处理量级。总体而言，我们的元分析数据符合这两个大脑区域在处理奖励量级方面可能具有不同作用的观点。（C）2012爱思唯尔有限公司。保留所有权利。
Reward maximization is a core motivation of every organism. In humans, several brain regions have been implicated in the representation of reward magnitude. Still, it is unclear whether identical brain regions consistently play a role in reward prediction and its consumption. In this study we used coordinate-based ALE meta-analysis to determine the individual roles of the ventral striatum (vSTR) and the medial orbitofrontal cortex (mOFC/VMPFC) in the representation of reward in general and of reward magnitude in particular. Specifically, we wanted to assess commonalities and differences in regional brain activation during the passive anticipation and consumption of rewards. Two independent meta-analyses of neuroimaging data from the past decade revealed a general role for the vSTR in reward anticipation and consumption. This was the case particularly when the consumed rewards occurred unexpectedly or were uncertain. In contrast, for the mOFC/VMPFC the present meta-analytic data suggested a rather specific function in reward consumption as opposed to passive anticipation. Importantly, when considering only coordinates that compared different reward magnitudes, the same parts of the vSTR and the mOFC/VMPFC showed concordant responses across studies, although areas of coherence were regionally more confined. These meta-analytic data suggest that the vSTR may be involved in both prediction and consumption of salient rewards, and may also be sensitive to different reward magnitudes, while the mOFC/VMPFC may rather process the magnitude during reward receipt. Collectively, our meta-analytic data conform with the notion that these two brain regions may subserve different roles in processing of reward magnitude. (C) 2012 Elsevier Ltd. All rights reserved.