miR-146b-5p inhibits glioma migration and invasion by targeting MMP16
miR-146b-5p inhibits glioma migration and invasion by targeting MMP16
复制标题
miR-146b-5p通过靶向MMP16抑制胶质瘤迁移和侵袭
DOI：
10.1016/j.canlet.2013.06.018
复制
发表时间：
2013-10-10
期刊：
影响因子：
9.7
通讯作者：
Kong, Yanling
中科院分区：
文献类型：
--
作者：
Li, Yanyan;Wang, Ying;Kong, Yanling
miR-146b-5p在实体肿瘤中经常下调，包括前列腺癌、胰腺癌和胶质母细胞瘤。然而，miR-146b-5p在恶性胶质瘤中的肿瘤抑制作用尚未得到深入研究。在这里，我们发现miR-146b-5p表达降低与胶质瘤，尤其是胶质母细胞瘤中染色体10q缺失密切相关。在胶质母细胞瘤细胞系中过表达miR-146b-5p导致MMP16 mRNA沉默，MMP2失活，抑制肿瘤细胞迁移和侵袭。我们的研究结果表明，恢复miR-146b-5p的表达可能是抑制恶性胶质瘤迁移和侵袭的可行途径。2013爱思唯尔爱尔兰有限公司版权所有。
miR-146b-5p is frequently down-regulated in solid tumours, including prostate cancer, pancreatic cancer, and glioblastoma. However, the tumour-suppressive effects of miR-146b-5p in malignant gliomas have not been investigated thoroughly. Here, we found that decreased miR-146b-5p expression was strongly correlated with chromosome 10q loss in gliomas, especially glioblastomas. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. Our results suggest that the restoration of miR-146b-5p expression may be a feasible approach for inhibiting the migration and invasion of malignant gliomas. (C) 2013 Elsevier Ireland Ltd. All rights reserved.