Bioactive sphingolipids: metabolism and function
Bioactive sphingolipids: metabolism and function
复制标题
DOI：
10.1194/jlr.r800080-jlr200
复制
发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Hannun, Yusuf A.
中科院分区：
文献类型：
--
作者：
Bartke, Nana;Hannun, Yusuf A.
鞘脂（SLs）是真核细胞的重要成分。神经酰胺、鞘氨醇、鞘氨醇-1-磷酸等代谢产物除了在细胞膜中发挥结构作用外，还作为调控细胞生长、分化、衰老和凋亡的生物活性信号分子而受到关注。了解SL代谢物的许多细胞调节功能需要对它们在细胞中如何以及在何处产生、转化或降解有深入的了解。这篇综述将简要介绍SLs的代谢、定位和区隔。此外，还将讨论SL家族的生物活性成员和导致神经酰胺生成的SL酶的诱导剂。——巴特克和汉农生物活性鞘脂：代谢和功能。[j] .油脂杂志。2009。S91-S96。
Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural roles in cellular membranes, some metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate, have drawn attention as bioactive signaling molecules involved in the regulation of cell growth, differentiation, senescence, and apoptosis. Understanding the many cell regulatory functions of SL metabolites requires an advanced knowledge of how and where in the cell they are generated, converted, or degraded.jlr This review will provide a short overview of the metabolism, localization, and compartmentalization of SLs. Also, a discussion on bioactive members of the SL family and inducers of SL enzymes that lead to ceramide generation will be presented. -Bartke, N., and Y. A. Hannun. Bioactive sphingolipids: metabolism and function. J. Lipid Res. 2009. S91-S96.