Dynamic expression and essential functions of Hes7 in somite segmentation
Dynamic expression and essential functions of Hes7 in somite segmentation
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DOI：
10.1101/gad.930601
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发表时间：
2001-10-15
影响因子：
10.5
通讯作者：
Kageyama, R
中科院分区：
文献类型：
--
作者：
Bessho, Y;Sakata, R;Kageyama, R
基本螺旋-环-螺旋 (bHLH) 基因 Hes7 是一种假定的 Notch 效应子，编码转录抑制子。在这里，我们发现 Hes7 表达在个体前中胚层 (PSM) 中以 2 小时为周期振荡。在 Hes7 缺失的小鼠中，体节无法正确分割，并且它们的前后极性被破坏。结果，椎骨和肋骨等体节衍生物严重混乱。尽管Notch及其配体的表达没有受到显着影响，但振荡器和Notch调节剂疯狂边缘在整个突变PSM中持续表达。这些结果表明 Hes7 控制疯子边缘的循环表达，对于协调体节分割至关重要。
The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior-posterior polarity is disrupted. As a result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although expression of Notch and its ligands is not affected significantly, the oscillator and Notch modulator lunatic fringe is expressed continuously throughout the mutant PSM. These results indicate that Hes7 controls the cyclic expression of lunatic fringe and is essential for coordinated somite segmentation.