Isolation and characterization of a Chinese strain of human enterovirus 74 from a healthy child in the Tibet Autonomous Region of China
Isolation and characterization of a Chinese strain of human enterovirus 74 from a healthy child in the Tibet Autonomous Region of China
复制标题
从中国西藏自治区健康儿童中分离和鉴定人类肠道病毒 74 型中国株
DOI：
10.1007/s00705-012-1332-9
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发表时间：
2012-08-01
影响因子：
2.7
通讯作者：
Xu, Wenbo
中科院分区：
文献类型：
--
作者：
Wang, Jitao;Zhang, Yong;Xu, Wenbo
人肠道病毒74型（HEV 74）是最近在人肠道病毒B（HEV-B）种内描述的血清型。HEV 74的核苷酸序列很少，只有一个完整的基因组序列（原型株）已被公布。在这项研究中，我们报告了在中国西藏自治区粪便调查期间从一名健康儿童中分离的HEV 74株的全基因组序列。结果表明，HEV 74可能是一种流行的常见肠道病毒型，并且HEV 74在全球范围内分布，特别是在亚洲。序列分析显示HEV 74株之间的高度变异性，并表明在HEV-B内频繁重组。
Human enterovirus 74 (HEV74) is a recently described serotype within the species Human enterovirus B (HEV-B). Few nucleotide sequences of HEV74 are available, and only one complete genome sequence (the prototype strain) has been published. In this study, we report the complete genome sequence of an HEV74 strain isolated from a healthy child during a stool survey in the Tibet Autonomous Region of China. The results indicated that HEV74 may be a prevalent and common enterovirus type, and that HEV74 is globally distributed, especially in Asia. Sequence analysis revealed high variability among HEV74 strains and indicated frequent recombination within HEV-B.