Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor
Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor
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DOI：
10.1002/chem.201903531
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发表时间：
2019-10-24
影响因子：
4.3
通讯作者：
Nakamura, Hiroyuki
中科院分区：
文献类型：
--
作者：
Fuse, Shinichiro;Masuda, Koshiro;Nakamura, Hiroyuki
使用无保护氨基酸和混合碳酸酐实现了多肽链的延长。微流技术使含有保护性多肽或保护性二肽的有机层和含有非保护性氨基酸或非保护性二肽的水层快速混合，以加速所需的酰胺化反应，从而成功地抑制了不需要的外消旋/差向异构化。更多信息可在S.Fuse等人的全文中找到。(DOI：10.1002/Chem.201903531)。
Peptide-chain elongation using unprotected amino acids with mixed carbonic anhydride was achieved. Micro-flow technology enabled the rapid mixing of an organic layer, containing a protected peptide or a protected dipeptide, and an aqueous layer, containing an unprotected amino acid or an unprotected dipeptide to accelerate the desired amidation, which successfully suppressed the undesired racemization/epimerization. More information can be found in the Full Paper by S. Fuse et al. (DOI: 10.1002/chem.201903531).