Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model
Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model
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DOI：
10.1002/biot.201700703
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发表时间：
2019-10-01
影响因子：
4.7
通讯作者：
Zhang, Yu Shrike
中科院分区：
文献类型：
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作者：
Duchamp, Margaux;Liu, Tingting;Zhang, Yu Shrike
由于传统生物制造技术在模拟复杂肿瘤微环境方面的局限性，肿瘤组织工程仍然具有挑战性。在这里，据报道，利用牺牲生物打印策略在水凝胶基质内产生仿生乳腺导管样结构，其进一步填充有乳腺癌细胞，以模拟导管癌的发生及其随后的向外侵袭。这种生物打印的乳腺导管癌模型提供了使用牺牲生物打印技术用于工程化生物相关癌症模型的价值的概念验证，其可能扩展到涉及导管样结构的其他癌症类型。
Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.