Merkel Cell Carcinoma Histologic Features and Prognosis
Merkel Cell Carcinoma Histologic Features and Prognosis
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DOI：
10.1002/cncr.23874
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发表时间：
2008-11-01
期刊：
影响因子：
6.2
通讯作者：
Busam, Klaus J.
中科院分区：
文献类型：
--
作者：
Andea, Aleodor A.;Coit, Daniel G.;Busam, Klaus J.
背景。目前，组织学特征对原发性皮肤神经内分泌（默克尔细胞）癌（MCC）的潜在预后价值知之甚少。在一项肿瘤组织学和临床结果数据的回顾性研究中(中位随访时间为51个月；我们对156例诊断为MCC的患者的以下组织学特征进行了评估：肿瘤厚度、肿瘤大小（肿瘤的最大尺寸）、肿瘤累及的显微解剖腔室（真皮和/或皮下和/或更深）、肿瘤生长模式（结节性局限vs浸润性）、淋巴血管浸润（LVI）、肿瘤浸润淋巴细胞、肿瘤坏死、溃疡和太阳弹性。总5年生存率为67.5%。在单因素分析中，与生存率显著相关的参数是肿瘤厚度（P = 0.001）、肿瘤大小（P = 0.0002）、肿瘤累及的最深解剖腔室（P = 0.0003）、肿瘤生长模式（P = 0.003）、LVI （P < 0.00001）、肿瘤浸润淋巴细胞（P = 0.05）和太阳弹性增生（P = 0.04）。在多变量分析中，结节生长模式、低肿瘤深度和无LVI的存在与较长的生存期相关。除了已知的肿瘤分期的预后价值外，3个组织学特征被确定为具有预后意义：特纳厚度（结节浸润深度），LVI的存在和轻微的生长模式。癌症2008;113:2549-58。(C) 2008年美国癌症协会。
BACKGROUND. Currently, little is known regarding the potential prognostic value of histologic features in primary Cutaneous neuroendocrine (Merkel cell) carcinomas (MCC).METHODS. in a retrospective review of the tumor histology and clinical outcome data (median follow-tip, 51 months; range, 3-224 months) of 156 patients with a diagnosis of MCC, the following histologic features were evaluated: tumor thickness, tumor size (greatest dimension of the tumor), microanatomic compartment involved by tumor (dermis and/or subcutis and/or deeper), tumor growth pattern (nodular circumscribed vs infiltrative), lymphovascular invasion (LVI), tumor-infiltrating lymphocytes, tumor necrosis, ulceration, and solar elastosis.RESULTS. The overall 5-year survival rate was 67.5%. On univariate analysis, parameters that were associated significantly with Survival were tumor thickness (P = .001), turnor size (P = .0002), deepest anatomic compartment involved by tumor (P = .0003), tumor growth pattern (P = .003), LVI (P < .00001), tumor-infiltrating lymphocytes (P = .05), and solar elastosis (P = .04). On multivariate analysis, the presence of a nodular growth pattern, low tumor depth, and absence of LVI were associated with longer Survival.CONCLUSIONS. In addition to the known prognostic value Of tumor stage, 3 histologic features were identified to have prognostic significance: turner thickness (depth of turnor invasion), the presence of LVI, and Minor growth pattern. Cancer 2008; 113:2549-58. (C) 2008 American Cancer Society.