Travel histories as risk factors in the analysis of urban malaria in Colombia
Travel histories as risk factors in the analysis of urban malaria in Colombia
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DOI：
10.4269/ajtmh.2004.71.380
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发表时间：
2004-10-01
影响因子：
3.3
通讯作者：
Bradley, DJ
中科院分区：
文献类型：
--
作者：
Osorio, L;Todd, J;Bradley, DJ
在一项病例对照研究中，使用了自我报告的旅行史，以确定当地居民向邻近流行区的移动是否是哥伦比亚Quibdo镇疟疾的危险因素。多变量分析显示，在Quibdo居民中，发病前8-14天前往流行区是恶性疟原虫（校正比值比[OR] = 28.96，95%置信区间[CI] = 13.9-60.32）和间日疟原虫（校正OR = 14.24，95% CI = 5.27-38.46）疟疾的最强危险因素。对于恶性疟原虫，在发病前8-14天内没有到基布多以外旅行，但在发病前1-7天，15-21天或22-30天报告旅行的人患疟疾的风险也增加了。相反，使用防蚊措施与恶性疟原虫呈负相关。这些结果突出表明，需要采取针对移动的人口的疟疾控制措施。提出了输入性疟疾的定义，允许在基布多镇从本地病例输入的区别。
Self-reported travel histories were used in a case-control study to determine whether movement of local residents to neighboring endemic areas was a risk factor for malaria in the town of Quibdo, Colombia. Multivariate analyses showed that among residents of Quibdo, traveling to an endemic area 8-14 days before disease onset was the strongest risk factor for both Plasmodium falciparum (adjusted odds ratio [OR] = 28.96, 95% confidence interval [CI] = 13.9-60.32) and P. vivax (adjusted OR = 14.24, 95% CI = 5.27-38.46) malaria. For P. falciparum, individuals who did not travel outside Quibdo during the 8-14 days before disease onset, but who reported traveling 1-7, 15-21, or 22-30 days before disease onset also had an increased risk of malaria. Conversely, use of protection against mosquitoes was negatively associated with P. falciparum. These results highlight the need for malaria control measures that target mobile populations. A definition of imported malaria that allows distinction of imported from autochthonous cases in Quibdo town is proposed.