Cognitive deficits as treatment targets in schizophrenia
Cognitive deficits as treatment targets in schizophrenia
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DOI：
10.1016/j.schres.2004.09.008
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发表时间：
2004-12-15
影响因子：
4.5
通讯作者：
Gold, JM
中科院分区：
文献类型：
--
作者：
Gold, JM
认知障碍已经成为精神分裂症治疗中的一个重要的新靶点，因为有证据表明认知缺陷与疾病特征性的功能障碍密切相关。简要回顾了支持精神分裂症认知障碍是治疗干预的有吸引力的目标这一观点的证据，包括：（1）有一个非常高频率发生的认知缺陷的特征模式;（2）随着时间的推移，这些缺陷相对稳定;（3）认知缺陷相对独立于疾病的症状表现。因此，认知障碍似乎是一种定义明确、可靠和独特的疾病。(C)2004年由Elsevier B. V.出版
Cognitive impairment has emerged as an important new target in schizophrenia therapeutics in light of evidence that cognitive deficits are critically related to the functional of disability that is characteristic of the illness. Evidence is briefly reviewed supporting the idea that the cognitive impairment in schizophrenia is an attractive target for therapeutic intervention including: (1) there is a characteristic pattern of cognitive deficits that occur with very high frequency; (2) the deficits are relatively stable over time; and (3) cognitive deficits are relatively independent of the symptomatic manifestations of the illness. Thus, cognitive impairment appears to be a well-defined, reliable and distinct dimension of the illness. (C) 2004 Published by Elsevier B.V.