Actions of desoxynupharidine hydrochloride in the central nervous system of experimental animals (I).
Actions of desoxynupharidine hydrochloride in the central nervous system of experimental animals (I).
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盐酸脱氧荸荠啶对实验动物中枢神经系统的作用（一）。
DOI：
10.1254/jjp.31.391
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
T. Ikeda
中科院分区：
文献类型：
--
作者：
Y. Suzuki;Y. Hagiwara;K. Taguchi;K. Kajiyama;T. Ikeda
本文研究了丝瓜络提取物盐酸脱氧鸟苷（DN）对中枢神经系统的作用。在急性猫中，DN（1-3 mg/kg，i. v.）在下丘脑外侧核和杏仁核产生8-10 Hz的波，海马唤醒波让位于不规则的高振幅慢波。中脑网状结构、网状核和皮质12-13 Hz波和高幅慢波增多。所有脑电图的一般模式均为睡眠样模式和梭形爆发样波。这些自发脑电活动被盐酸肾上腺素显著抑制，而盐酸妥拉苏林、盐酸二苯那明等则增强。DN可抑制高频刺激坐骨神经引起的脑电唤醒反应，提高刺激阈值。在慢性猫中，DN（1 mg/kg，i. v.）在皮层产生12-14 Hz的纺锤形爆发样波，并伴随镇静作用。提示DN对中枢神经系统有抑制作用，可能与肾上腺素能神经元有关。
The effects of desoxynupharidine hydrochloride (DN) as the extractive component of the Nuphar japonicum DC on the central nervous system were studied. In the acute cats, DN (1-3 mg/kg, i.v.) produced 8-10 Hz waves in the hypothalamus lateralis and amygdala, and the hippocampal arousal wave gave way to the irregular high amplitude slow waves. In the midbrain reticular formation, nucl. reticularis and cortex, 12-13 Hz waves and high amplitude slow waves increased. A sleep-like pattern with spindle burst-like waves formed the general pattern of all EEGs. These spontaneous EEG activities were significantly inhibited by epinephrine hydrochloride and were potentiated by tolazoline hydrochloride and dibenamine hydrochloride etc. The above EEG changes were obtained even in the spinal cats. DN depressed the EEG arousal response produced by high frequency stimulation of the sciatic nerve and increased the threshold of stimulation. In the chronic cats, DN (1 mg/kg, i.v.) produced spindle burst-like waves of 12-14 Hz in the cortex and sedation concomitantly. These findings suggest that DN has an inhibitory effect on the central nervous system and that adrenergic neurons are probably involved.