Replacement of progesterone with a phenothiazine in the induction of maternal behavior in the ovariectomized nulliparous rat.
Replacement of progesterone with a phenothiazine in the induction of maternal behavior in the ovariectomized nulliparous rat.
复制标题
用吩噻嗪替代黄体酮诱导去势未产大鼠的母性行为。
DOI：
10.1016/0031-9384(71)90265-4
复制
发表时间：
1971
影响因子：
2.9
通讯作者：
M. Lubin
中科院分区：
文献类型：
--
作者：
H. Moltz;M. Leon;M. Numan;M. Lubin
当在孕激素戒断的背景下注射雌激素和催乳素时，在卵巢切除的未生育大鼠中诱导完全的母性行为。提出的假设是，孕激素首先提高激活阈值内的母亲调解系统，然后，在撤出，这些阈值降低到低于正常水平。正是在这种假定的神经元兴奋性增强的状态下，雌激素和催乳素被描绘成能够作用于中介系统，以促进对年轻人的视觉、声音和气味的反应。这一假说意味着，一种能够影响由于孕酮戒断而引起的“反弹”的药物应该在母性行为的诱导中取代孕酮。选择奋乃静（氯吩噻嗪的氨基衍生物）是因为其对皮质和皮质下脑区活动阈值的双相作用。在注射包括雌激素和催乳素的注射方案中使用奋乃静代替孕酮，发现奋乃静在诱导母性行为方面与孕酮一样有效。这些数据支持了关于孕酮戒断对母体介导系统的启动效应的假设。
Full maternal behavior is induced in the ovariectomized nulliparous rat when estrogen and prolactin are injected against a background of progesterone withdrawal. The hypothesis advanced was that progesterone at first elevates activation thresholds within the maternal mediating system and then, upon withdrawal, decreases these thresholds to levels lower than normal. It is during this presumed state of heightened neuronal excitability that estrogen and prolactin are pictured as being able to act on the mediating system to facilitate responsiveness to the sight, sound and odor of young. This hypothesis implies that an agent capable of effecting the kind of “rebound” attributed to the withdrawal of progesterone should substitute for progesterone in the induction of maternal behavior. Perphenazine, an amino derivative of chlorophenothiazine, was selected because of its demonstrated biphasic action on activity thresholds in cortical and subcortical brain areas. Used in place of progesterone in an injection schedule that included estrogen and prolactin, perphenazine was found as effective as progesterone in inducing maternal behavior. The data were held to support the hypothesis regarding the priming effect of progesterone-withdrawal on the maternal mediating system.