IGA DEPOSITION IN ALCOHOLIC LIVER-DISEASE
IGA DEPOSITION IN ALCOHOLIC LIVER-DISEASE
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DOI：
10.1136/jcp.39.11.1181
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发表时间：
1986-11-01
影响因子：
3.4
通讯作者：
BOYLSTON, AW
中科院分区：
文献类型：
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作者：
GOLDIN, RD;CATTLE, S;BOYLSTON, AW
使用间接免疫过氧化物酶技术研究了酒精性和非酒精性肝病的免疫球蛋白沉积。连续的IgA沉积模式，IgA勾勒出血窦，被证明是肝硬化和非肝硬化肝脏中酒精引起的肝脏疾病的特异性和敏感标志物。仅表现脂肪改变的酒精性疾病的敏感性最低。在一个病例中，有可能在药物引起的肝脏疾病中显示IgA的缺失，这在组织学上与酒精性肝炎无法区分。
Immunoglobulin deposition in alcoholic and non-alcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrhotic and non-cirrhotic livers. The sensitivity was lowest in cases of alcoholic disease showing fatty change alone. In one case it was possible to show the absence of IgA in liver disease caused by a drug, which was histologically indistinguishable from alcoholic hepatitis.