Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group
Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group
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利用重原子效应开发光敏8-偶氮香豆素型不稳定性保护基团
DOI：
10.1021/acs.orglett.5b02720
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发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
and Hirokazu Tamamura
中科院分区：
文献类型：
--
作者：
Hikaru Takano;Tetsuo Narumi;Wataru Nomura;Toshiaki Furuta;and Hirokazu Tamamura
通过碘取代，香豆素型可光性保护基团的光化学性质得到了显著改善。新发现的7-羟基-6-碘-8-偶氮素（8-偶氮素- ihc）笼化乙酸酯具有优异的光解效率，显著高于相应的含溴型香豆素和偶氮素型笼化基团。研究结果为提高光敏性保护基团的光敏性提供了坚实的途径。
A remarkable improvement of the photochemical properties of coumarin-type photolabile protecting groups was achieved by iodine substitution. The newly identified 7-hydroxy-6-iodo-8-azacoumarin (8-aza-Ihc)-caged acetate showed excellent photolytic efficiency, significantly higher than that of the corresponding bromine-containing coumarin- and azacoumarin-type caging groups. The results provide a solid approach to improving the photosensitivity of photolabile protecting groups.