Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.
Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.
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肿瘤发展过程中大鼠肺胚胎上皮细胞伴随 p53 基因突变和放射敏感性增加。
作者：
D. Biard;M. Martin;Y. L. Rhun;A. Duthu;J. Lefaix;E. May;P. May
用苯并（a）芘处理大鼠肺细胞群，并从中衍生出一组不同的上皮细胞系，这些细胞系携带野生型或突变型p53基因，并代表肿瘤发展的分级状态。我们在这里证明，与携带野生型p53等位基因的细胞相比，缺乏两种野生型p53等位基因的细胞在2至12戈伊剂量的γ射线照射后存活率显著降低。这是第一个报道的模型，其中携带p53基因突变的细胞显示对电离辐射的敏感性增强。
A rat lung cell population had been treated with benzo(a)pyrene, and a set of different epithelial cell lines was derived from it. These cell lines carried either a wild-type or mutant p53 gene and represented grading states of neoplastic development. We demonstrate here that the cells lacking both wild-type p53 alleles display a significant decrease in survival after gamma-irradiation with doses of 2 to 12 Gy, compared with their counterparts carrying wild-type p53 alleles. This is the first reported model in which cells bearing a mutation of the p53 gene display enhanced sensitivity to ionizing radiation.
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影响因子：
11.2
作者：
W. Slichenmyer;W. Nelson;R. Slebos;M. Kastan
通讯作者：
W. Slichenmyer;W. Nelson;R. Slebos;M. Kastan
影响因子：
11.2
作者：
David Brachman;Michael A. Beckett;D. Graves;D. Haraf;E. Vokes;R. Weichselbaum
通讯作者：
David Brachman;Michael A. Beckett;D. Graves;D. Haraf;E. Vokes;R. Weichselbaum
p53 突变体的新 DNA 结合及其在转录激活中的作用。
影响因子：
8
作者：
Zhang,W;Funk,WD;Wright,WE;Shay,JW;Deisseroth,AB
通讯作者：
Deisseroth,AB
DOI：
10.1073/pnas.89.16.7491
发表时间：
1992-08-15
影响因子：
11.1
作者：
KUERBITZ, SJ;PLUNKETT, BS;KASTAN, MB
通讯作者：
KASTAN, MB