A model of the mechanics of airway narrowing.
A model of the mechanics of airway narrowing.
复制标题
气道变窄的机制模型。
DOI：
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发表时间：
1990
影响因子：
3.3
通讯作者：
P. Paré
中科院分区：
文献类型：
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作者：
B. Wiggs;R. Moreno;J. Hogg;C. Hilliam;P. Paré
为了研究气道平滑肌缩短和气道壁增厚对肺阻力变化的相互作用，我们开发了一个气管支气管树模型，可以模拟气道狭窄的机制。该模型基于Weibel所描述的对称二分分支气管支气管树，采用Pedley等人提出的流体动力学方程计算静潮呼吸时的吸气阻力。为了考虑肺容量的变化，我们使用了Lambert等人开发的气道压力-面积曲线。该模型很容易实现与电子表格和个人电脑，允许计算总和局部肺阻力。在模型的每一代气道中，都规定了气道壁厚度，可实现的最大气道平滑肌缩短，并给出了s形的剂量-反应关系来描述平滑肌缩短。为了验证模型的有效性，我们将模型生成的压力-流量曲线与正常受试者在不同肺容量下呼吸空气和20% O2-80% He时的肺阻力测量结果进行了比较。通过模拟进行性气道平滑肌缩短，产生了真实的肺阻力与剂量-反应曲线。我们的结论是，该模型提供了肺阻力的现实估计，并显示了检查疾病中可能产生过度气道狭窄的各种机制的潜力。
To examine the interaction between airway smooth muscle shortening and airway wall thickening on changes in pulmonary resistance, we have developed a model of the tracheobronchial tree that allows simulation of the mechanisms involved in airway narrowing. The model is based on the symmetrical dichotomous branching tracheobronchial tree as described by Weibel and uses fluid dynamic equations proposed by Pedley et al. to calculate inspiratory resistance during quiet tidal breathing. To allow for changes in lung volume, we used the airway pressure-area curves developed by Lambert et al. The model is easily implemented with a spreadsheet and personal computer that allows calculation of total and regional pulmonary resistance. At each airway generation in the model, provision is made for airway wall thickness, the maximal airway smooth muscle shortening achievable, and an S-shaped dose-response relationship to describe smooth muscle shortening. To test the validity of the model, we compared pressure-flow curves generated with the model with measurements of pulmonary resistance while normal subjects breathed air and 20% O2-80% He at a variety of lung volumes. By simulating progressive airway smooth muscle shortening, realistic pulmonary resistance vs. dose-response curves were produced. We conclude that this model provides realistic estimates of pulmonary resistance and shows potential for examining the various mechanisms that could produce excessive airway narrowing in disease.