Expression of Fgfr2 in the early mouse embryo indicates its involvement in preimplantation development
Expression of Fgfr2 in the early mouse embryo indicates its involvement in preimplantation development
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DOI：
10.1016/s0925-4773(99)00082-9
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发表时间：
1999-07-01
影响因子：
2.6
通讯作者：
Lonai, P
中科院分区：
文献类型：
--
作者：
Haffner-Krausz, R;Gorivodsky, M;Lonai, P
我们报告说，IIIc转录替代Fgfr 2在未受精卵转录，并在早期合子转录，信息编码的Fgfr 2替代品（IIIc和IIIb）的存在。Fgfr 2蛋白首先在致密桑椹胚的外周卵裂球中检测到。Fgfr 2的滋养外胚层特异性在早期囊胚中变得明显，随着成熟，其定位进一步特化，在胚极Fgfr 2浓度增加，在胚极Fgfr 2浓度降低。此外，Fgfr 2表达沿成熟胚泡的动物-植物轴沿着变得明显不对称。我们的观察表明Fgfr 2在滋养外胚层的生长和规格，并在植入前孕体的方向和极性的作用。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
We report that the IIIc transcriptional alternative of Fgfr2 is transcribed in the unfertilized egg and that during early zygotic transcription, messages encoded by both Fgfr2 alternatives (IIIc and IIIb) are present. The Fgfr2 protein was first detected in peripheral blastomeres of compacted morulae. Trophectoderm specificity of Fgfr2 became obvious in the early blastocyst and with maturation its localization underwent further specification, Fgfr2 concentration increased at the abembryonic pole and decreased at the embryonic pole. Moreover Fgfr2 expression became markedly asymmetrical along the animal-vegetal axis of the mature blastocyst. Our observations indicate a role for Fgfr2 in trophectoderm growth and specification and in the orientation and polarity of the preimplantation conceptus. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.