PREVENTION OF SIV INFECTION IN MACAQUES BY (R)-9-(2-PHOSPHONYLMETHOXYPROPYL)ADENINE
PREVENTION OF SIV INFECTION IN MACAQUES BY (R)-9-(2-PHOSPHONYLMETHOXYPROPYL)ADENINE
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DOI：
10.1126/science.270.5239.1197
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发表时间：
1995-11-17
期刊：
影响因子：
56.9
通讯作者：
BLACK, R
中科院分区：
文献类型：
--
作者：
TSAI, CC;FOLLIS, KE;BLACK, R
以猕猴为人类免疫缺陷病毒(HIV)模型，研究了抗病毒化合物(R)-9-(2-膦甲氧基丙基)腺嘌呤(PMPA)暴露前后对猴免疫缺陷病毒(SIV)的影响。从接种病毒前48小时、接种后4小时或接种后24小时开始，每天皮下注射PMPA一次。治疗持续了4周，对猕猴的病毒学、免疫学和临床状态进行了长达56周的监测。PMPA在所有猕猴中预防SIV感染，而没有毒性，而所有对照猕猴都被感染。这些结果表明，在已知暴露的情况下，PMPA预防早期艾滋病毒感染具有潜在的作用。
The efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV). PMPA was administered subcutaneously once daily beginning either 48 hours before, 4 hours after, or 24 hours after virus inoculation. Treatment continued for 4 weeks and the virologic, immunologic, and clinical status of the macaques was monitored for up to 56 weeks. PMPA prevented SIV infection in all macaques without toxicity, whereas all control macaques became infected. These results suggest a potential role for PMPA prophylaxis against early HIV infection in cases of known exposure.