Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers
Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers
复制标题
非病毒基因载体的结构与功能关系：抗菌聚合物的经验教训
DOI：
10.1016/j.actbio.2018.12.041
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发表时间：
2019
影响因子：
9.7
通讯作者：
Pingtian Ding
中科院分区：
文献类型：
--
作者：
Haonan Xing;Mei Lu;Tianzhi Yang;Hui Liu;Yanping Sun;Xiaoyun Zhao;Hui Xu;Li Yang;Pingtian Ding
近年来，在非病毒基因载体的设计和合成方面取得了重大进展。然而，缺乏有效和生物相容性载体仍然是阻碍其在临床应用的主要挑战。在过去的十年中，阳离子抗菌聚合物由于其对耐药微生物的有效、快速和广谱杀灭活性以及生物相容性的特点而迅速发展。鉴于抗菌聚合物与非病毒基因载体在膜亲和性、官能团、理化特性和独特的大分子结构等方面具有共同的特点，这些聚合物可以为我们克服设计新型载体的挑战提供灵感，从而在临床中实现更安全高效的基因传递。在这些观察的基础上，我们通过阐述一些关键的结构参数，包括官能团、电荷密度、疏水/亲水平衡、分子量和大分子结构，概述了聚合物在抗菌应用和基因传递方面的结构-功能关系。借助抗菌药物的发展，具有高转染效率和生物相容性的新型非病毒基因载体的开发将有很大的发展前景
In recent years, substantial advances have been achieved in the design and synthesis of nonviral gene vectors. However, lack of effective and biocompatible vectors still remains a major challenge that hinders their application in clinical settings. In the past decade, there has been a rapid expansion of cationic antimicrobial polymers, due to their potent, rapid, and broad-spectrum biocidal activity against resistant microbes, and biocompatible features. Given that antimicrobial polymers share common features with nonviral gene vectors in various aspects, such as membrane affinity, functional groups, physicochemical characteristics, and unique macromolecular architectures, these polymers may provide us with inspirations to overcome challenges in the design of novel vectors toward more safe and efficient gene delivery in clinic. Building off these observations, we provide here an overview of the structure-function relationships of polymers for both antimicrobial applications and gene delivery by elaborating some key structural parameters, including functional groups, charge density, hydrophobic/hydrophilic balance, MW, and macromolecular architectures. By borrowing a leaf from antimicrobial agents, great advancement in the development of newer nonviral gene vectors with high transfection efficiency and biocompatibility will be more promising