Adipose-derived adult stem cells: isolation, characterization, and differentiation potential
Adipose-derived adult stem cells: isolation, characterization, and differentiation potential
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DOI：
10.1080/14653240310003026
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发表时间：
2003-01-01
期刊：
影响因子：
4.5
通讯作者：
Guilak, F
中科院分区：
文献类型：
--
作者：
Gimble, JM;Guilak, F
脂肪组织是成体干细胞的丰富、可获取且可补充的来源，可以通过胶原酶消化和差速离心从抽脂废组织中分离出来。这些脂肪来源的成体干 (ADAS) 细胞是多能的，可沿脂肪细胞、软骨细胞、肌细胞、神经元和成骨细胞谱系分化，并且可以发挥其他功能，例如提供造血支持和基因转移。 ADAS 细胞在急性和慢性受损组织的修复和再生方面具有潜在的应用。在完全实现这些细胞的前景之前，还需要进行额外的临床前安全性和功效研究。
Adipose tissue is an abundant, accessible, and replenisbable source of adult stem cells that can be isolated from liposuction Waste tissue by collagenase digestion and differential centrifugation. These adipose-derived adult stem (ADAS) cells are multipotent, differentiating along the adipocyte, chondrocyte, myocyte, neuronal, and osteoblast lineages, and can serve in other capacities, such as providing hematopoietic support and gene transfer. ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues. Additional pre-clinical safety and efficacy studies will be needed before the promise of these cells can be fully realized.