What strategies do ulcerative colitis patients employ to facilitate adherence?
What strategies do ulcerative colitis patients employ to facilitate adherence?
复制标题
DOI：
10.2147/ppa.s117841
复制
发表时间：
2017
影响因子：
2.2
通讯作者：
Yamamoto-Mitani N
中科院分区：
文献类型：
--
作者：
Kawakami A;Tanaka M;Naganuma M;Maeda S;Kunisaki R;Yamamoto-Mitani N
总体而言，30%-45%的溃疡性结肠炎(UC)患者没有坚持服药，服药有困难；这种不坚持会使临床复发的风险增加1.4-5.5倍。这项研究的目的是阐明患者采用的促进依从性的策略，并确定这些策略是否对良好的依从性有影响。这是一项使用自填式问卷和回顾医疗记录的横断面调查。纳入2009年6月至2012年12月期间在四家城市医院门诊就诊的确诊为UC的患者。开发了一份问卷，以确定患者采用的促进依从性的策略，然后对UC患者进行管理。计算对5-氨基水杨酸的依从性，并进行单变量和多元Logistic回归分析，以确定与良好依从性相关的策略。最终的分析包括671名参与者(平均年龄40.2岁；54.3%的男性)。有效应答率为96.9%，未依从者186人(27.7%)，平均依从率86.1%(标准差17.9)。研究确定了患者用于促进依从性的七种策略，以下两种策略与良好的依从性显著相关：“我把药放在吃饭的地方”和“我把每天的药放在一个药盒里或类似的东西里，以确保我服用了它们”。确定的策略可能被用于开发一项计划，以改善UC患者的用药依从性。
Overall, 30%–45% of patients with ulcerative colitis (UC) are non-adherent and have difficulties taking their medications; this non-adherence increases the risk of clinical relapse 1.4- to 5.5-fold. This study aimed to clarify the strategies patients employ to facilitate adherence and determine whether the strategies had an impact on good adherence. This was a cross-sectional survey using a self-administered questionnaire and review of medical records. Patients diagnosed as having UC and attending one of the outpatient clinics of four urban hospitals from June 2009 to December 2012 were enrolled. A questionnaire was developed to identify the strategies patients employ to facilitate adherence and then administered to patients with UC. Adherence to 5-aminosalicylic acid was calculated, and univariate and multiple logistic regression analyses were performed to determine the strategies that were associated with good adherence. The final analyses included 671 participants (mean age 40.2 years; 54.3% males). The valid response rate was 96.9%; 186 (27.7%) participants were classified as non-adherent, the mean adherence rate being 86.1% (standard deviation [SD] 17.9). Seven strategies that patients employ to facilitate adherence were identified, the following two being significantly associated with good adherence: “I keep my medicines where I eat meals” and “I keep each day’s medicine in a pill case or something similar to make sure I have taken them”. The identified strategies might be used to develop a program to improve medication adherence in patients with UC.