25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia.
25-Hydroxyvitamin D and metabolic-related laboratory values in women with schizophrenia and hyperprolactinemia.
复制标题
患有精神分裂症和高催乳素血症的女性的 25-羟基维生素 D 和代谢相关实验室值。
DOI：
10.1016/j.jpsychires.2022.03.046
复制
发表时间：
2022
影响因子：
4.8
通讯作者：
Kelly,DeannaL
中科院分区：
文献类型：
--
作者：
Nallani,MadhulikaC;Powell,MeganM;Pugh,Sharon;Kearns,AnnMarie;Adams,HeatherA;Weiner,Elaine;Wehring,HeidiJ;McEvoy,JosephP;Buckley,PeterF;Liu,Fang;Buchanan,RobertW;Kelly,DeannaL
精神分裂症是一种严重的精神障碍，伴有多种内科合并症和早期死亡。高催乳素血症在女性中很常见，其对性功能、泌乳和闭经的影响是众所周知的。本文评估了患有高泌乳素血症的精神分裂症女性（N = 43）25-羟基维生素D缺乏症和其他代谢相关实验室异常的风险。这些妇女的平均催乳素水平为88.5 ± 56.0 ng/mL。我们发现100%的妇女超重，其中74%（32/43）的妇女肥胖，56%（23/41）的妇女总胆固醇水平异常，30%（13/43）的妇女空腹血糖高。37%的女性认为维生素D水平不足或不足。我们没有看到催乳素与实验室指标的显著相关性，但是所有女性患者的催乳素水平均升高，导致小样本的变异性较低，这可能排除了任何直接关系。认识到催乳素相关的副作用，并了解其他健康措施的作用，在女性患者抗精神病药诱导的高催乳素血症的女性，是更好地个性化的护理和恢复的关键步骤。
Schizophrenia is a severe mental disorder with various medical comorbidities and early mortality. Hyperprolactinemia is common in women and its impact on sexual function, galactorrhea and amenorrhea is well known. This paper evaluates the risk of 25-hydroxy vitamin D deficiency and other metabolic related laboratory abnormalities in women with schizophrenia having hyperprolactinemia (N = 43). The mean prolactin level in these women was 88.5 ± 56.0 ng/mL. We found that 100% of women were overweight of which 74% (32/43) of the women were obese, 56% (23/41) had abnormal total cholesterol levels and 30% (13/43) had high fasting blood glucose. Vitamin D levels were considered deficient or inadequate in 37% of women. We did not see significant correlations of prolactin with laboratory measures, however all female patients had elevated and high prolactin levels, leading to low variability in a small sample, which may have precluded seeing any direct relationships. Recognizing prolactin related side effects and understanding the role of other health measures seen in women with antipsychotic induced hyperprolactinemia in our female patients are critical steps toward better personalization of their care and recovery.