Current use and development of fish vaccines in China.
Current use and development of fish vaccines in China.
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我国鱼苗疫苗的使用和开发现状。
DOI：
10.1016/j.fsi.2019.12.010
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发表时间：
2020
影响因子：
4.7
通讯作者：
Zhen Xu
中科院分区：
文献类型：
--
作者：
Qingchao Wang;Wei Ji;Zhen Xu
在过去的几十年里，中国的水产养殖业取得了巨大的发展，贡献了世界养殖鱼类产量的70%以上。沿着水产品产量的快速增长，水产养殖病害的发生和暴发数量也在不断增加，给水产养殖业和食品安全带来了严重危害。从效率、安全、环保和伦理方面考虑，疫苗绝对是控制各种鱼类疾病的最合适和最有针对性的方法。我国在鱼用疫苗方面做了大量的研究工作，目前已有6种国产鱼用疫苗产品沿着1种进口鱼用疫苗获得国家兽药证书。更为关键的是，一些新疫苗也进入田间试验阶段，并展现出广阔的市场前景。本文综述了草鱼出血病活疫苗、鱼源气单胞菌脓毒症灭活疫苗、大菱鲆迟缓爱德华氏菌活疫苗、溶藻弧菌、副溶血性弧菌和大肠杆菌抗独特型抗体疫苗等7种水产疫苗的研究进展。草鱼出血病细胞培养灭活疫苗、鱼传染性脾肾坏死病毒（ISKNV）灭活疫苗和STV基因工程活疫苗。大菱鳗此外，还比较了鱼类疫苗不同的接种途径，以及沿着不同的鱼类免疫应答。所有这些努力最终将有利于中国水产养殖业的健康和可持续发展。
In the past decades, the aquaculture industry made great progress in China, which contributes more than 70% yield of the world's farmed fish. Along with the rapid growth of fish production, increased emergence and outbreak of numbers of diseases pose harm to the aquaculture industry and food safety. From the efficient, safe, environmental and ethical aspects, vaccines is definitely the most appropriate and focused method to control different kinds of fish diseases. In China, researchers have done huge works on the fish vaccines, and so far six domestic aquatic vaccine products along with one imported aquatic vaccine have obtained the national veterinary medicine certificate. More critically, some new vaccines have also entered the field experiment stage and showed broad market prospects. In the present review, authors summarize seven aquatic vaccines, including the live vaccine against grass carp hemorrhagic disease, the inactivated vaccine against Aeromonas hydrophila sepsis in fish, the live vaccine against Edwardsiella tarda in turbot, the anti-idiotypic antibody vaccine against Vibrio alginolyticus,V. parahaemolyticus, andE. tardain Japanese flounder, the cell-cultured inactivated vaccine against grass carp hemorrhagic disease, the inactivated vaccine against fish infectious spleen and kidney necrosis virus (ISKNV), and the genetically engineered live vaccine againstV. anguillarumin turbot. Moreover, different delivery routes of fish vaccines are also compared in this review, along with differential fish immune response after vaccination. All these efforts will ultimately benefit the healthy and sustainable development of aquaculture industry in China.