Fluid mechanics as a driver of tissue-scale mechanical signaling in organogenesis.
Fluid mechanics as a driver of tissue-scale mechanical signaling in organogenesis.
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流体力学是组织尺度机械信号传导的驱动因素。
DOI：
10.1007/s40139-016-0117-3
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发表时间：
2016-12
影响因子：
--
通讯作者：
Gleghorn JP
中科院分区：
文献类型：
--
作者：
Gilbert RM;Morgan JT;Marcin ES;Gleghorn JP
器官发生是指细胞在发育过程中自组装成复杂的、多尺度的组织。尽管大量的焦点和研究工作已经证明了固体力学在器官发生中的重要性，但很少有人关注在组织长度尺度上提供机械线索的流体力。流体运动和压力能够产生作用于细胞的力的空间梯度，从而引发对适当器官形成至关重要的独特和局部信号模式。了解力学的多尺度性质对于破译机械信号如何塑造发育中的器官至关重要。这篇综述概述了组织产生、调节和感知流体力的各种机制，并在正常和病理发育的案例研究中强调了这些力和机制的影响。
Organogenesis is the process during development by which cells self-assemble into complex, multi-scale tissues. Whereas significant focus and research effort has demonstrated the importance of solid mechanics in organogenesis, less attention has been given to the fluid forces that provide mechanical cues over tissue length scales. Fluid motion and pressure is capable of creating spatial gradients of forces acting on cells, thus eliciting distinct and localized signaling patterns essential for proper organ formation. Understanding the multi-scale nature of the mechanics is critically important to decipher how mechanical signals sculpt developing organs. This review outlines various mechanisms by which tissues generate, regulate, and sense fluid forces and highlights the impact of these forces and mechanisms in case studies of normal and pathological development.