Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.
Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.
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组蛋白修饰酶：发育决策的调节剂和人类疾病的驱动因素。
作者：
Butler JS;Koutelou E;Schibler AC;Dent SY
精确的转录网络驱动着复杂发育过程的协调和执行。具有序列特异性DNA结合特性的转录因子以逐步的方式激活或抑制靶基因以控制大多数细胞谱系决定。这种调节通常需要转录因子和大量蛋白质复合物的亚基之间的相互作用，这些蛋白质复合物具有针对组蛋白的酶促活性。转录蛋白和组蛋白修饰剂的功能偶联强调了通过染色质修饰在发育细胞命运决定和疾病发病机制中的转录调控的重要性。
Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.