Prevalence of Dry Eye at High Altitude: A Case Controlled Comparative Study
Prevalence of Dry Eye at High Altitude: A Case Controlled Comparative Study
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DOI：
10.1089/ham.2007.1055
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发表时间：
2008-12-01
影响因子：
2.1
通讯作者：
D'Souza, Pamela
中科院分区：
文献类型：
--
作者：
Gupta, Noopur;Prasad, Indira;D'Souza, Pamela
Gupta, Noopur, Indira Prasad， G. Himashree和Pamela D'Souza。干眼症在高海拔地区的患病率：一项病例对照比较研究。中国生物医学工程杂志，2009,31(2):327-333。-高海拔与眼睛的生理和病理变化有关，这些变化与不利的环境条件有关，导致泪液蒸发增加，并导致这些地区干眼症的发生率更高。我们的目的是研究干眼症在高海拔和低海拔地区的患病率差异。并对当地居民和新近派驻高海拔地区的军人的干眼症患病率进行了研究和比较。200名20岁以上的成年人被招募。在印度新德里低海拔地区（海拔218 m，温度19℃~ 24℃）筛选年龄、性别相匹配的100名受试者作为对照组。采用标准问卷（McMonnies问卷（MMI）、眼表疾病指数问卷（OSDI）和Schirmer基础分泌物试验）评估干眼症的患病率。根据所研究的参数（症状、MMI、OSDI和Schirmer试验），在高海拔地区筛查的受试者中有20%被诊断为干眼症，在低海拔地区筛查的对照组中有9%被诊断为干眼症。在研究组中，干眼症的患病率在当地人口中（54%）明显高于最近派驻该地区的士兵（26%）。差异有统计学意义（p < 0.005）。总之，干眼症在高海拔地区更为常见，尤其是在当地人群中。需要提高居住在高海拔地区的人们和治疗干眼症的医务人员的意识，以便及早发现和治疗干眼症，防止危及视力的并发症。
Gupta, Noopur, Indira Prasad, G. Himashree, and Pamela D'Souza. Prevalence of dry eye at high altitude: a case controlled comparative study. High Alt. Med. Biol. 9: 327-333, 2008.-High altitude is associated with physiological as well as pathological changes in the eye related to adverse environmental conditions that result in increased tear evaporation and contribute to a higher incidence of dry eye in these regions. We aimed to study the difference in prevalence of dry eye at high altitude and at low altitude. The prevalence of dry eye among the natives and the army soldiers who were recently posted at high altitude was also studied and compared. 200 adults above 20 years of age were enrolled. 100 subjects were recruited at a high altitude region (study group), of which 50 were native Ladakhis and 50 were soldiers recently posted at Leh, Ladakh, India (height; 3300 m above sea level; temperature: 18 degrees C to 24 degrees C). 100 subjects, age and sex matched, were screened at a low altitude region, New Delhi, India (218 m above sea level; temperature: 19 degrees C to 24 degrees C) to serve as the control group. Prevalence of dry eye was assessed through standard questionnaires (McMonnies' Questionnaire (MMI), Ocular Surface Disease Index Questionnaire (OSDI), and Schirmer's basic secretion test. On the basis of the parameters studied (symptoms, MMI, OSDI and Schirmer's test), dry eye was diagnosed in 20% of subjects screened at high altitude and in 9% of subjects in the control group screened at low altitude. In the study group, the prevalence of dry eye was significantly higher amongst the native population (54%) than in the army soldiers who were recently posted at that region (26%). The difference was statistically significant (p < 0.005). In conclusion, dry eye is more common at high altitude, particularly in the native population. Awareness among people residing at high altitude and the treating medical personnel needs to be created for early detection and treatment of dry eye to prevent vision-threatening complications.