Monocular cells without ocular dominance columns
Monocular cells without ocular dominance columns
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DOI：
10.1152/jn.00131.2006
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发表时间：
2006-11-01
影响因子：
2.5
通讯作者：
Horton, Jonathan C.
中科院分区：
文献类型：
--
作者：
Adams, Daniel L.;Horton, Jonathan C.
在哺乳动物大脑皮层的许多区域中，具有共同感受野特性的细胞被分组为柱。尽管进行了大量研究，但皮质柱的功能仍然未知。在松鼠猴中，眼优势柱的表达是可变的，一些动物存在眼优势柱，而另一些动物则不存在。通过寻找有柱子和没有柱子的动物之间的差异，应该可以推断出柱子如何促进视觉处理。在 9 只松鼠猴中进行 4C 层外的单细胞记录，然后在 4C 层中标记眼优势列。在松鼠猴中，与猕猴相比，无论是否存在眼优势柱，4C 层外的细胞更有可能对任一只眼睛的刺激做出反应。在三只缺乏眼优势列的动物中，从 4C 层记录单细胞。值得注意的是，尽管没有柱，但 4C 层中有 20% 的细胞是单眼的。这一观察结果意味着，眼优势柱对于纹状皮层中出现的单眼细胞来说不是必需的。在猕猴中，每一行细胞色素氧化酶 (CO) 斑块与眼优势列对齐，并接收仅服务于一只眼睛的 koniocellular 输入。在松鼠猴中，情况并非如此：CO 斑块和眼优势柱没有空间相关性，并且 CO 斑块的眼细胞输入是双眼的。因此，即使松鼠猴出现眼优势柱，它们也不会改变功能结构以类似于猕猴。
In many regions of the mammalian cerebral cortex, cells that share a common receptive field property are grouped into columns. Despite intensive study, the function of the cortical column remains unknown. In the squirrel monkey, the expression of ocular dominance columns is variable, with columns present in some animals and not in others. By searching for differences between animals with and without columns, it should be possible to infer how columns contribute to visual processing. Single-cell recordings outside layer 4C were made in nine squirrel monkeys, followed by labeling of ocular dominance columns in layer 4C. In the squirrel monkey, compared with the macaque, cells outside layer 4C were more likely to respond to stimulation of either eye whether ocular dominance columns were present or not. In three animals lacking ocular dominance columns, single cells were recorded from layer 4C. Remarkably, 20% of cells in layer 4C were monocular despite the absence of columns. This observation means that ocular dominance columns are not necessary for monocular cells to occur in striate cortex. In macaques each row of cytochrome oxidase ( CO) patches is aligned with an ocular dominance column and receives koniocellular input serving one eye only. In squirrel monkeys this was not true: CO patches and ocular dominance columns had no spatial correlation and the koniocellular input to CO patches was binocular. Thus even when ocular dominance columns occur in the squirrel monkey, they do not transform the functional architecture to resemble that of the macaque.