Endocytic sorting of transmembrane protein cargo
Endocytic sorting of transmembrane protein cargo
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DOI：
10.1016/j.ceb.2011.03.004
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发表时间：
2011-08-01
影响因子：
7.5
通讯作者：
Owen, David J.
中科院分区：
文献类型：
--
作者：
Kelly, Bernard T.;Owen, David J.
跨膜蛋白在细胞膜结合细胞器中的准确分布和再循环对于确保其正确功能至关重要。预定用于网格蛋白介导的内吞作用和沿内吞途径沿着转运的跨膜蛋白质货物通过与衔接子的相互作用分选到转运囊泡中，衔接子同时将网格蛋白连接到膜。网格蛋白衔接子识别货物蛋白的细胞质部分中存在的各种信号;最近的结构、生物物理和细胞生物学研究已经阐明了新型的货物-衔接子相互作用，并探索了调节货物选择和囊泡成熟的分子机制。在这里，我们回顾这一最新进展的背景下，我们现有的知识内吞分选机制。
The accurate distribution and recycling of transmembrane proteins amongst the membrane-bound organelles of the cell is vital to ensure its correct functioning. Transmembrane protein cargo destined for clathrin-mediated endocytosis and transport along the endocytic pathway is sorted into transport vesicles by interactions with adaptors, which simultaneously link clathrin to the membrane. Clathrin adaptors recognize a variety of signals present in the cytoplasmic portions of cargo proteins; recent structural, biophysical and cell biological studies have elucidated new types of cargo-adaptor interactions and probed the molecular mechanisms regulating cargo selection and vesicle maturation. Here, we review this recent progress in the context of our existing knowledge of endocytic sorting mechanisms.