Sampling the antibiotic resistome
Sampling the antibiotic resistome
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DOI：
10.1126/science.1120800
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发表时间：
2006-01-20
期刊：
影响因子：
56.9
通讯作者：
Wright, GD
中科院分区：
文献类型：
--
作者：
D'Costa, VM;McGrann, KM;Wright, GD
微生物对抗生素的耐药性目前涵盖所有已知类别的天然和合成化合物。它不仅阻碍了我们对感染的治疗，而且极大地改变了药物的发现，但它的起源还没有得到系统的研究。土壤细菌产生并遇到无数的抗生素，进化出相应的传感和逃避策略。它们是可以被动员到微生物群落中的抗性决定因素的储存库。对该储库的研究可以为未来临床相关的抗生素耐药机制提供早期预警系统。
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.