Oral methotrexate for recurrent brain tumors in children: a Pediatric Oncology Group study.
Oral methotrexate for recurrent brain tumors in children: a Pediatric Oncology Group study.
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口服甲氨蝶呤治疗儿童复发性脑肿瘤：一项儿科肿瘤学小组研究。
DOI：
10.1097/00043426-200001000-00008
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Kadota,RP
中科院分区：
文献类型：
--
作者：
Mulne,AF;Ducore,JM;Elterman,RD;Friedman,HS;Krischer,JP;Kun,LE;Shuster,JJ;Kadota,RP
目的：患有复发性或进展性中枢神经系统（CNS）肿瘤的儿童预后不良。根据儿科肿瘤组（POG）机构试点数据，对小剂量口服甲氨蝶呤（MTX）进行了研究。结果：完全或部分缓解率分别为：星形细胞瘤2/10，恶性胶质瘤1/19，髓母细胞瘤0/18，脑干肿瘤0/12，室管膜瘤1/7，其他组织学类型0/12。主要毒副反应，粘膜炎，骨髓抑制，肝转氨酶升高被认为是tolerable.Conclusion：低剂量口服MTX对恶性胶质瘤，髓母细胞瘤，脑干肿瘤，和杂项组织类型没有显着的活性。在星形细胞瘤和室管膜瘤儿童中观察到的反应率不确定但较低。不建议将该方案用于一线治疗。
Purpose:Children with recurrent or progressive central nervous system (CNS) tumors have an unfavorable prognosis. Based on Pediatric Oncology Group (POG) institutional pilot data, low-dose oral methotrexate (MTX) was studied.Methods:Eight dosages of MTX 7.5 mg/m 2 every 6 hours were administered on a weekly schedule for as long as 18 months. Patients in six different brain tumor strata were accrued.Results:The response rates (complete or partial responses) were as follows: astrocytoma 2 of 10, malignant glioma 1 of 19, medulloblastoma 0 of 18, brainstem tumor 0 of 12, ependymoma 1 of 7, and miscellaneous histologic types 0 of 12. The main toxicities, mucositis, myelosuppression, and hepatic transaminase elevation were considered tolerable.Conclusion:Low-dose oral MTX showed no significant activity against malignant glioma, medulloblastoma, brainstem tumors, and miscellaneous histologic types. Indeterminate but low response rates were observed in children with astrocytoma and ependymoma. This regimen will not be recommended for front-line therapy.
星形细胞瘤对大剂量甲氨蝶呤联合柠檬酸因子拯救的反应
影响因子：
6.2
作者：
I. Djerassi;Jung Sun Kim;A. Reggev
通讯作者：
A. Reggev
甲氨蝶呤对 L5178Y/Asn- 淋巴母细胞的细胞毒性：剂量和暴露时间与肿瘤细胞活力的关系。
影响因子：
11.2
作者：
D. Keefe;R. Capizzi;S. Rudnick
通讯作者：
S. Rudnick
放射前大剂量静脉注射甲氨蝶呤联合甲酰四氢叶酸可挽救未经治疗的原发性儿童脑肿瘤。
影响因子：
45.3
作者：
J. C. Allen;R. Walker;Gerald Rosen
通讯作者：
Gerald Rosen